戈洛帕米
戈洛帕米结构式
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常用名 | 戈洛帕米 | 英文名 | Gallopamil |
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| CAS号 | 16662-47-8 | 分子量 | 521.08900 | |
| 密度 | 1.068g/cm3 | 沸点 | 605.9ºC at 760mmHg | |
| 分子式 | C28H40N2O5 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 320.2ºC |
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Force response to stretches in activated frog muscle fibres at low tension.
Adv. Exp. Med. Biol. 538 , 429-38; discussion 438-9, (2003)
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Ca2+ pathway involved in the refilling of store sites in rat adrenal medullary cells.
Am. J. Physiol. Cell Physiol. 296(4) , C889-99, (2009) It has been suggested that store-operated Ca(2+) entry (SOC) facilitates catecholamine secretion and synthesis in bovine adrenal medullary (AM) cells. However, there has been no experimental result clearly showing that cation channel activity is enhanced by s... |
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Effects of phenylalkylamines and benzothiazepines on Ca(v)1.3-mediated Ca2+ currents in neonatal mouse inner hair cells.
Eur. J. Pharmacol. 573(1-3) , 39-48, (2007) Calcium currents (I(Ca)) in inner hair cells (IHCs) are carried by the Ca(v)1.3 subtype of L-type calcium channels. They play an important role in synaptic transmission of sound-evoked mechanical stimuli. L-type calcium channels are targets of the organic blo... |
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Insulin stimulates Ca2+ uptake via PKC, cAMP, and p38 MAPK in mouse embryonic stem cells.
Life Sci. 76(25) , 2903-19, (2005) Embryonic stem (ES) cells are provided as a powerful tool for developmental biology and have been shown to respond to insulin. However, little is known about the effect of insulin on [Ca2+]i regulation in the ES cells, although many cellular functions are tig... |
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A selective beta2-adrenergic agonist, terbutaline, improves sepsis-induced diaphragmatic dysfunction in the rat.
Life Sci. 79(9) , 905-12, (2006) Sepsis causes diaphragmatic dysfunction, which can lead to the development of respiratory failure. We previously reported that isoproterenol, non-selective beta-adrenergic agonist, improved contractility of the diaphragm in a septic rat model. Since beta(2)-a... |
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Nitric oxide involvement in pancreatic beta cell apoptosis by glibenclamide.
Nitric Oxide 14(1) , 39-44, (2006) Glibenclamide as a second-generation compound of sulfonylurea has widely been used in the treatment of type 2 diabetes patients. It has been shown that it induces apoptosis in beta cells, which is partially mediated by Ca(2+) influx. Here, we investigated the... |
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Reduction in extracellular Ca2+ attenuates endothelium-dependent relaxation more than nitroprusside-induced relaxation.
Acta Pharmacol. Sin. 31(1) , 19-26, (2010) To quantitatively assess the effect of lowering external Ca(2+) ([Ca(2+)](o)) on both endothelium-dependent and -independent relaxations in rabbit aorta.Isometric contractions and relaxations of isolated aortae were recorded. When assessing the effect of redu... |
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Pharmacophoric features and Ca2+ ion holding capacity of verapamil.
Bioorg. Med. Chem. Lett. 15(24) , 5412-5, (2005) Ab initio Hartree-Fock calculations have been performed at the 6-31G level to study the pharmacophoric features of verapamil. Both the unprotonated and the protonated forms of verapamil have been studied. The study predicts that the drug enters the body in pr... |
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L-type Ca2+ channel antagonists block voltage-dependent Ca2+ channels in identified leech neurons.
Brain Res. 1013(2) , 159-67, (2004) We investigated the effect of L-type Ca2+ channel antagonists on the Ca2+ influx through voltage-gated Ca2+ channels in leech Retzius, Leydig, AP, AE, P, and N neurons. The efficacy of the antagonists was quantified by monitoring their effect on the increase ... |
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NMDA receptor-mediated depolarizing after-potentials in the basal dendrites of CA1 pyramidal neurons.
Neurosci. Res. 48(3) , 325-33, (2004) It was shown recently that the basal dendrites of cortical pyramidal neurons generate NMDA-spikes. In the present study, we made whole-cell recordings from hippocampal CA1 pyramidal neurons and examined whether NMDA receptor activation was involved in synapti... |