N-硝基-L-精氨酸甲酯
N-硝基-L-精氨酸甲酯结构式
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常用名 | N-硝基-L-精氨酸甲酯 | 英文名 | L-NAME HCl |
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| CAS号 | 51298-62-5 | 分子量 | 269.686 | |
| 密度 | N/A | 沸点 | 383.5ºC at 760 mmHg | |
| 分子式 | C7H16ClN5O4 | 熔点 | 157-161 °C (dec.) | |
| MSDS | 美版 | 闪点 | 185.8ºC |
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Calcium entry and α-synuclein inclusions elevate dendritic mitochondrial oxidant stress in dopaminergic neurons.
J. Neurosci. 33(24) , 10154-64, (2013) The core motor symptoms of Parkinson's disease (PD) are attributable to the degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNc). Mitochondrial oxidant stress is widely viewed a major factor in PD pathogenesis. Previous work has sh... |
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Nitric oxide enhances extracellular ATP induced Ca²⁺ oscillation in HeLa cells.
Arch. Biochem. Biophys. 565 , 68-75, (2015) Calcium (Ca(2+)) oscillations play a central role in varieties of cellular processes including fertilization and immune response, but controversy over the regulation mechanisms still exists. It has been known that nitric oxide (NO) dependently regulates Ca(2+... |
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Involvement of H1 and H2 receptors and soluble guanylate cyclase in histamine-induced relaxation of rat mesenteric collecting lymphatics.
Microcirculation 21(7) , 593-605, (2014) This study investigated the roles of the H1 and H2 histamine receptors, NO synthase, and sGC cyclase in histamine-induced modulation of rat mesenteric collecting lymphatic pumping.Isolated rat mesenteric collecting lymphatics were treated with 1- to 100-μM hi... |
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Echinocystic acid, isolated from Gleditsia sinensis fruit, protects endothelial progenitor cells from damage caused by oxLDL via the Akt/eNOS pathway.
Life Sci. 114(2) , 62-9, (2014) Our previous studies revealed that echinocystic acid (EA) showed obvious attenuation of atherosclerosis in rabbits fed a high-fat diet. However, the underlying mechanisms remain to be elucidated. Considering the importance of endothelial progenitor cells (EPC... |
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The influence of L-NAME on iNOS expression and markers of oxidative stress in allergen-induced airway hyperreactivity.
Adv. Exp. Med. Biol. 838 , 1-10, (2015) Nitric oxide (NO) effects in airways are influenced by the activity of NO-synthase isoforms and NO metabolism. Inducible NO-synthase (iNOS), which produces large amounts of NO, is active during the inflammatory process. NO quickly reacts, producing reactive o... |
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Imatinib mesylate (Gleevec) induces human corpus cavernosum relaxation by inhibiting receptor tyrosine kinases (RTKs): identification of new RTK targets.
Urology 82(3) , 745.e11-6, (2013) To evaluate the effect of the tyrosine kinase inhibitor imatinib mesylate (Gleevec) on human corpus cavernosum (HCC) smooth muscle tone.HCC were obtained from 18 erectile dysfunction (ED) patients undergoing penile prosthesis surgery. The effects of imatinib ... |
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Mechanisms of vasorelaxation to gamma-mangostin in the rat aorta.
J. Med. Assoc. Thai. 95 Suppl 12 , S63-8, (2012) To investigate the effects of gamma-mangostin on vascular tone and its mechanisms in the isolated rat aorta.Aortic rings from male Wistar rats were precontracted with methoxamine. Changes in tension were measured using an isometric force transducer and record... |
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Role of nitric oxide synthase isoforms for ophthalmic artery reactivity in mice.
Exp. Eye Res. 127 , 1-8, (2014) Nitric oxide synthases (NOS) are involved in regulation of ocular vascular tone and blood flow. While endothelial NOS (eNOS) has recently been shown to mediate endothelium-dependent vasodilation in mouse retinal arterioles, the contribution of individual NOS ... |
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Effects of Phikud Navakot extract on vascular reactivity in the isolated rat aorta.
J. Med. Assoc. Thai. 95 Suppl 12 , S1-7, (2012) The aim of the present study is to investigate the effect of standardized Phikud Navakot extract (NVKE) on aortic rings from male Sprague Dawley rats. Changes in tension were measured using an isometric force transducer and recorded on the PowerLab recording ... |
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Nitric oxide directly promotes vascular endothelial insulin transport.
Diabetes 62(12) , 4030-42, (2013) Insulin resistance strongly associates with decreased nitric oxide (NO) bioavailability and endothelial dysfunction. In the vasculature, NO mediates multiple processes that affect insulin delivery, including dilating both resistance and terminal arterioles in... |