L-NAME HCl structure
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Common Name | L-NAME HCl | ||
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CAS Number | 51298-62-5 | Molecular Weight | 269.686 | |
Density | N/A | Boiling Point | 383.5ºC at 760 mmHg | |
Molecular Formula | C7H16ClN5O4 | Melting Point | 157-161 °C (dec.) | |
MSDS | USA | Flash Point | 185.8ºC |
Use of L-NAME HClL-NAME hydrochloride inhibits NOS with an IC50 of 70 μM. L-NAME is a precursor to NOS inhibitor L-NOARG which has an IC50 value of 1.4 μM. |
Name | N'-Nitro-L-arginine-methyl ester hydrochloride |
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Synonym | More Synonyms |
Description | L-NAME hydrochloride inhibits NOS with an IC50 of 70 μM. L-NAME is a precursor to NOS inhibitor L-NOARG which has an IC50 value of 1.4 μM. |
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Related Catalog | |
Target |
IC50: 70 μM (NOS)[1] |
In Vitro | L-arginine analogues are widely used inhibitors of nitric oxide synthase (NOS) activity, with Nw-nitro-L-arginine methyl ester (L-NAME) being at the head[2]. Freshly dissolved L-NAME is a 50 fold less potent inhibitor of purified brain NOS (mean IC50= 70 μM) than L-NOARG (IC50= 1.4 μM), but the apparent inhibitory potency of L-NAME approached that of L-NOARG upon prolonged incubation at neutral or alkaline pH. HPLC analyses reveal that NOS inhibition by L-NAME closely correlated with hydrolysis of the drug to L-NOARG[1]. |
In Vivo | L-NAME infusion significantly decreases NKT-leukocyte level, tumor-necrosis factor (TNF)-alpha production by T-splenocytes and macrophages, and interferon-gamma production by T-leukocytes, monocytes, and T-splenocytes, as well as increased interleukin-6 production by T-leukocytes and monocytes and nitrate/nitrite production by T-leukocytes[3]. There is increasing evidence that nitric oxide may be involved in learning and memory. l-NAME produces a task-dependent impairment of fear extinction, and implies that nitric oxide signaling is involved in memory process of certain fear extinction tasks[4]. Chronic L-NAME administration induces cardiac hypertrophy in rodent models. Six weeks L-NAME administration induces significant cardiac hypertrophy compared to control hearts[5]. |
Animal Admin | Rats: The purpose is to investigate dose effects of chronically infused NOS inhibitor, LNAME on the anabolism, inflammatory responses, and arginine metabolism in parenterally fed rats with cecal puncture-induced subacute peritonitis. Male Wistar rats (8-9 weeks old), initially weighing 250 g, are used in the study. Rats are divided into 4 groups and are administered total parenteral nutrition solutions with 0, 5 (low dose), 25 (medium dose), or 50 (high dose) mg/kg per day of L-NAME for 7 days[3]. Mice: 12-20 week old C57BL/6J mice (5 per group) are administered L-NAME (0.325mg/mL) in the drinking water. Hearts are excised at 1-day, 2-days, 5-days, 2-weeks or 6-weeks; or controls which received no L-NAME. Ventricular cross-sectional wall thickness and individual cardiac myocytes cross-sectional area and cardiomyocyte/nuclear ratio to determine cardiac hypertrophy. Immuno-histochemical staining for c-kit, sca-1 and BCRP undertaken[5]. |
References |
Boiling Point | 383.5ºC at 760 mmHg |
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Melting Point | 157-161 °C (dec.) |
Molecular Formula | C7H16ClN5O4 |
Molecular Weight | 269.686 |
Flash Point | 185.8ºC |
Exact Mass | 269.089081 |
PSA | 146.05000 |
LogP | 1.47960 |
Index of Refraction | 15 ° (C=3, MeOH) |
Storage condition | 2~8°C |
Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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Hazard Codes | Xn |
Risk Phrases | R22 |
Safety Phrases | S22-S24/25 |
RIDADR | NONH for all modes of transport |
WGK Germany | 3 |
Precursor 0 | |
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DownStream 1 | |
Calcium entry and α-synuclein inclusions elevate dendritic mitochondrial oxidant stress in dopaminergic neurons.
J. Neurosci. 33(24) , 10154-64, (2013) The core motor symptoms of Parkinson's disease (PD) are attributable to the degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNc). Mitochondrial oxidant stress is widely vie... |
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Nitric oxide enhances extracellular ATP induced Ca²⁺ oscillation in HeLa cells.
Arch. Biochem. Biophys. 565 , 68-75, (2015) Calcium (Ca(2+)) oscillations play a central role in varieties of cellular processes including fertilization and immune response, but controversy over the regulation mechanisms still exists. It has be... |
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Involvement of H1 and H2 receptors and soluble guanylate cyclase in histamine-induced relaxation of rat mesenteric collecting lymphatics.
Microcirculation 21(7) , 593-605, (2014) This study investigated the roles of the H1 and H2 histamine receptors, NO synthase, and sGC cyclase in histamine-induced modulation of rat mesenteric collecting lymphatic pumping.Isolated rat mesente... |
LNAME hydrochloride |
Nitro-L-arginine Methyl Ester Hydrochloride |
MFCD00039052 |
N(γ)-nitro-L-arginine methyl ester hydrochloride |
N'-Nitro-L-arginine methyl ester hydrochloride |
Methyl (E)-N-[amino(nitroamino)methylene]-L-ornithinate hydrochloride (1:1) |
L-NAME hydrochloride |
methyl (2S)-2-amino-5-[[amino(nitramido)methylidene]amino]pentanoate,hydrochloride |
Nω-Nitro-L-arginine Methyl Ester Hydrochloride |
NG-Nitro-L-arginine-methyl ester hydrochloride |
EINECS 257-116-1 |
L-Ornithine, N-[amino(nitroamino)methylene]-, methyl ester, (E)-, hydrochloride (1:1) |
N-Nitro-L-Arginine methyl ester hydrochloride |
(S)-Methyl 2-amino-5-(3-nitroguanidino)pentanoate hydrochloride |
H-Arg(NO2)-Ome·Hcl |
H-Arg(NO2)-Ome.HCl |
N'-Nitro-L-arginine-methylester hydrochloride |
L-NAME (hydrochloride) |