新橙皮苷二氢查尔酮
新橙皮苷二氢查尔酮结构式
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常用名 | 新橙皮苷二氢查尔酮 | 英文名 | Neosperidin dihydrochalcone |
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| CAS号 | 20702-77-6 | 分子量 | 612.576 | |
| 密度 | 1.6±0.1 g/cm3 | 沸点 | 927.1±65.0 °C at 760 mmHg | |
| 分子式 | C28H36O15 | 熔点 | 156-158 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 302.6±27.8 °C |
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Protective effects of neohesperidin dihydrochalcone against carbon tetrachloride-induced oxidative damage in vivo and in vitro.
Chem. Biol. Interact. 213 , 51-9, (2014) The purpose of this study was to investigate the possible hepatoprotective effects of neohesperidin dihydrochalcone (NHDC) on carbon tetrachloride (CCl4)-induced acute oxidative injury in vivo and in vitro. In a mouse model, intraperitoneal injection of CCl4 ... |
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Determination of high-intensity sweeteners in river water and wastewater by solid-phase extraction and liquid chromatography-tandem mass spectrometry.
J. Chromatogr. A. 1393 , 106-14, (2015) High-intensity sweeteners have been suggested as potential organic contaminants due to their widespread use in food, drugs and sanitary products. As a consequence, they are introduced into the environment by different pathways, affecting aquatic life. In this... |
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Neohesperidin dihydrochalcone: presentation of a small molecule activator of mammalian alpha-amylase as an allosteric effector.
FEBS Lett. 587(6) , 652-8, (2013) Flavonoids and their precursor trans-chalcone have been reported as inhibitors of mammalian alpha-amylase. With regard to this background, neohesperidin dihydrochalcone (NHDC) effect was investigated toward porcine pancreatic alpha-amylase (PPA), and found to... |
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Determination of nine high-intensity sweeteners in various foods by high-performance liquid chromatography with mass spectrometric detection.
Anal. Bioanal. Chem 400 , 2159-72, (2011) An analytical procedure involving solid-phase extraction (SPE) and high-performance liquid chromatography-mass spectrometry has been developed for the determination of nine high-intensity sweeteners authorised in the EU; acesulfame-K (ACS-K), aspartame (ASP),... |
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Metabolic engineering of plant cells for biotransformation of hesperedin into neohesperidin, a substrate for production of the low-calorie sweetener and flavor enhancer NHDC.
J. Agric. Food Chem. 53(25) , 9708-12, (2005) Neohesperidin dihydrochalcone (NHDC) is a seminatural, safe, low-calorie sweetener, bitterness blocker, and flavor enhancer with unique properties and applications for the food, beverage, pharmaceutical, and animal feed industries. Current production is limit... |
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The binding site for neohesperidin dihydrochalcone at the human sweet taste receptor.
BMC Struct. Biol. 7 , 66, (2007) Differences in sweet taste perception among species depend on structural variations of the sweet taste receptor. The commercially used isovanillyl sweetener neohesperidin dihydrochalcone activates the human but not the rat sweet receptor TAS1R2+TAS1R3. Analys... |
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Validated high-performance liquid chromatographic method for quantitation of neohesperidine dihydrochalcone in foodstuffs.
J. Chromatogr. A. 758(1) , 163-6, (1997) An analytical method to detect and quantitate neohesperidine dihydrochalcone in foodstuffs has been developed and validated in soft-drink applications. The method was shown to be sufficiently precise, accurate, selective and rugged in quantitating neohesperid... |
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Subchronic (13-week) oral toxicity of neohesperidin dihydrochalcone in rats.
Food Chem. Toxicol. 28(7) , 507-13, (1990) Neohesperidin dihydrochalcone was administered to groups of 20 male and 20 female Wistar rats at dietary levels of 0, 0.2, 1.0 and 5.0% for 91 days. No treatment-related ophthalmoscopical, haematological or histopathological effects were observed. In the high... |
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Embryotoxicity and teratogenicity study with neohesperidin dihydrochalcone in rats.
Regul Toxicol Pharmacol 40(1) , 74-9, (2004) The embryotoxicity/teratogenicity of neohesperidin dihydrochalcone (NHDC) was examined in Wistar Crl:(WI)WU BR rats. NHDC was fed at dietary concentrations of 0, 1.25, 2.5 or 5 to groups of 28 mated female rats from day 0 to 21 of gestation. At Cesarean secti... |
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[Determination of neohesperidin dihydrochalcone in foods].
Shokuhin Eiseigaku Zasshi 42(1) , 40-4, (2001) An HPLC method was developed for the determination of neohesperidin dihydrochalcone (NHDC) in foods. A solid sample was extracted with methanol. The extract was evaporated and the residue was dissolved in methanol-water (2:8) mixture. In the case of fluid sam... |