盐酸纳曲酮
盐酸纳曲酮结构式
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常用名 | 盐酸纳曲酮 | 英文名 | Naltrexone Hydrochloride |
|---|---|---|---|---|
| CAS号 | 16676-29-2 | 分子量 | 377.862 | |
| 密度 | 1.47 g/cm3 | 沸点 | 558.1ºC at 760 mmHg | |
| 分子式 | C20H24ClNO4 | 熔点 | 274-2760C | |
| MSDS | 中文版 美版 | 闪点 | 291.4ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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Novel in situ gelling ocular films for the opioid growth factor-receptor antagonist-naltrexone hydrochloride: fabrication, mechanical properties, mucoadhesion, tolerability and stability studies.
Int. J. Pharm. 477(1-2) , 631-42, (2014) Naltrexone hydrochloride (NTX) is an innovative drug used in ophthalmology for treatment of ocular surface diseases such as impaired corneal wound healing and severe dry eye. Poor chemical stability has been a major limitation for development of NTX in soluti... |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Nat. Chem. Biol. 5 , 765-71, (2009) Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened seven parasite lines for differences in responses to 1,279... |
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Involvement of nitridergic and opioidergic pathways in the antinociception of gabapentin in the orofacial formalin test in mice.
Pharmacol. Rep. 67(2) , 399-403, (2015) Pain is one of the most common problems in clinical medicine. There is considerable evidence that pharmacologic approaches are the most widely used therapeutic options to ameliorate persistent or chronic pain. In this study it was evaluated the effect of l-NA... |
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Activation of TRPM7 channels by small molecules under physiological conditions.
Pflugers Arch. 466(12) , 2177-89, (2014) Transient receptor potential cation channel, subfamily M, member 7 (TRPM7) is a cation channel covalently linked to a protein kinase domain. TRPM7 is ubiquitously expressed and regulates key cellular processes such as Mg(2+) homeostasis, motility, and prolife... |
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Alleviating waiting impulsivity and perseverative responding by μ-opioid receptor antagonism in two inbred mouse strains.
Psychopharmacol. Ser. 232(8) , 1483-92, (2015) Recent evidence has implicated the opioid system in exaggerated ethanol consumption and impulsivity deficits. The opioid receptor antagonist naltrexone (NTX) has proven efficient in reducing alcohol consumption; however, its role on impulsive behaviour is not... |
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Phytochemical composition and antinociceptive activity of Bauhinia glauca subsp. hupehana in rats.
PLoS ONE 10(2) , e0117801, (2015) In traditional medicine, Bauhinia glauca subsp. hupehana has long been used as an analgesic agent in China. The aim of this study was to evaluate the antinociceptive activity of the ethanol extract of the aerial parts of B. glauca subsp. hupehana (BHE) in rat... |
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Polytherapy with a combination of three repurposed drugs (PXT3003) down-regulates Pmp22 over-expression and improves myelination, axonal and functional parameters in models of CMT1A neuropathy.
Orphanet J. Rare Dis. 9 , 201, (2015) Charcot-Marie-Tooth disease type 1A (CMT1A) is the most common inherited sensory and motor peripheral neuropathy. It is caused by PMP22 overexpression which leads to defects of peripheral myelination, loss of long axons, and progressive impairment then disabi... |
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The atypical antidepressant and neurorestorative agent tianeptine is a μ-opioid receptor agonist.
Transl. Psychiatry 4 , e411, (2014) Current pharmacological treatments of depression and related disorders suffer from major problems, such as a low rate of response, slow onset of therapeutic effects, loss of efficacy over time and serious side effects. Therefore, there is an urgent need to ex... |
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Dry eye reversal and corneal sensation restoration with topical naltrexone in diabetes mellitus.
Arch. Ophthal. 127 , 1468-73, (2010) To determine if topical application of naltrexone hydrochloride (NTX), an opioid antagonist, restores tear production and corneal sensation in rats with diabetes mellitus.Type 1 diabetes was induced with streptozotocin in rats. Tear production was measured by... |