5-溴-1-茚酮
5-溴-1-茚酮结构式
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常用名 | 5-溴-1-茚酮 | 英文名 | 5-Bromoindanone |
|---|---|---|---|---|
| CAS号 | 34598-49-7 | 分子量 | 211.06 | |
| 密度 | 1.6±0.1 g/cm3 | 沸点 | 303.7±31.0 °C at 760 mmHg | |
| 分子式 | C9H7BrO | 熔点 | 126-129 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 120.2±12.2 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Discovery of a series of imidazo[4,5-b]pyridines with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-γ.
J. Med. Chem. 54 , 4219-4233, (2011) Mining of an in-house collection of angiotensin II type 1 receptor antagonists to identify compounds with activity at the peroxisome proliferator-activated receptor-γ (PPARγ) revealed a new series of imidazo[4,5-b]pyridines 2 possessing activity at these two ... |
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Novel imidazolyl and triazolyl substituted biphenyl compounds: synthesis and evaluation as nonsteroidal inhibitors of human 17alpha-hydroxylase-C17, 20-lyase (P450 17).
Bioorg. Med. Chem. 8(6) , 1245-52, (2000) The synthesis of a new series of P450 17 inhibitors is described. The imidazol-1-yl compounds 5 showed strong inhibition of P450 17 rat and especially human enzyme, the most active compounds being 5ax, 5ay and 5bx with IC50 values of 0.17, 0.24 and 0.25 micro... |
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The identification of potent and selective imidazole-based inhibitors of B-Raf kinase.
Bioorg. Med. Chem. Lett. 16(2) , 378-381, (2006) A novel triarylimidazole derivative, SB-590885 (33), bearing a 2,3-dihydro-1H-inden-1-one oxime substituent has been identified as a potent and extremely selective inhibitor of B-Raf kinase. |
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Identification of a novel series of tetrahydrodibenzazocines as inhibitors of 17beta-hydroxysteroid dehydrogenase type 3.
Bioorg. Med. Chem. Lett. 16(6) , 1532-1536, (2006) A novel series of 17beta-hydroxysteroid dehydrogenase type 3 (17beta-HSD3) inhibitors has been identified. These inhibitors, based on a dibenzazocine core, exhibited picomolar to low nanomolar inhibition of 17beta-HSD3 in cell-free enzymatic as well as in cel... |
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Asymmetric Strecker-Type Reaction of alpha-Aryl Ketones. Synthesis of (S)-alphaM4CPG, (S)-MPPG, (S)-AIDA, and (S)-APICA, the Antagonists of Metabotropic Glutamate Receptors.
J. Org. Chem. 64(1) , 120-125, (1999) Heating a mixture of alpha-aryl ketone with (R)-phenylglycinol produces a mixture of imine and 1,3-dioxazolidine. Treatment of this mixture with trimethylsilyl cyanide followed by transformation of nitrile to ester gives Strecker-type reaction products. The d... |
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Enzymatic Baeyer-Villiger Oxidation of Benzo-Fused Ketones: Formation of Regiocomplementary Lactones. Rioz-Martinez A, et al.
European J. Org. Chem. 2009(15) , 2526-2532, (2009)
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Yaws CL.
The Yaws Handbook of Physical Properties for Hydrocarbons and Chemicals 2nd ed.,, (2015), 229
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Turn-On Fluorogenic Probes for the Selective and Quantitative Detection of the Cyanide Anion from Natural Sources. Gómez T, et al.
Chemistry 8(6) , 1271-1278, (2013)
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