胆色素原
胆色素原结构式
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常用名 | 胆色素原 | 英文名 | Porphobilinogen |
|---|---|---|---|---|
| CAS号 | 487-90-1 | 分子量 | 226.22900 | |
| 密度 | 1.421g/cm3 | 沸点 | 478.6ºC at 760 mmHg | |
| 分子式 | C10H14N2O4 | 熔点 | 174-177ºC | |
| MSDS | 中文版 美版 | 闪点 | 243.2ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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Inactivation of the ubiquitin-specific protease 19 deubiquitinating enzyme protects against muscle wasting.
FASEB J. 29 , 3889-98, (2015) The ubiquitin system plays a critical role in muscle wasting. Previous work has focused on the roles of ubiquitination. However, a role for deubiquitination in this process has not been established. Because ubiquitin-specific protease (USP)19 deubiquitinating... |
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Mass spectrometric characterisation of a condensation product between porphobilinogen and indolyl-3-acryloylglycine in urine of patients with acute intermittent porphyria.
J. Mass Spectrom. 50 , 929-37, (2015) We document the presence of a previously unknown species in the urine of patients with acute intermittent porphyria (AIP). The compound was fully characterised by liquid chromatography tandem mass spectrometry. Interpretation of both full spectrum acquisition... |
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Crosstalk between the mesothelium and lymphomatous cells: insight into the mechanisms involved in the progression of body cavity lymphomas.
Cancer Med. 3(1) , 1-13, (2014) The peculiar localization of body cavity lymphomas implies a specific contribution of the intracavitary microenvironment to the pathogenesis of these tumors. In this study, primary effusion lymphoma (PEL) was used as a model of body cavity lymphoma to investi... |
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CCI-779 (Temsirolimus) exhibits increased anti-tumor activity in low EGFR expressing HNSCC cell lines and is effective in cells with acquired resistance to cisplatin or cetuximab.
J. Transl. Med. 13 , 106, (2015) The mammalian target of rapamycin (mTOR) signaling pathway plays a pivotal role in numerous cellular processes involving growth, proliferation and survival. The purpose of this study was to investigate the anti-tumoral effect of the mTOR inhibitor (mTORi) CCI... |
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Biochemical, radiologic, ultrastructural, and genetic evaluation of iron overload in acute leukemia and iron-chelation therapy.
J. Pediatr. Hematol. Oncol. 36(4) , 281-92, (2014) Iron overload in hereditary hemochromatosis and hematologic malignancy has unfavorable effects on morbidity. Herein, 53 children (age 108.4±58.3 mo, 25 girls and 28 boys) with acute myeloblastic and lymphoblastic leukemia, who received 4 different chemotherap... |
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DNA binding and anti-cancer activity of redox-active heteroleptic piano-stool Ru(II), Rh(III), and Ir(III) complexes containing 4-(2-methoxypyridyl)phenyldipyrromethene.
Inorg. Chem. 52(7) , 3687-98, (2013) The synthesis of four novel heteroleptic dipyrrinato complexes [(η(6)-arene)RuCl(2-pcdpm)] (η(6)-arene = C6H6, 1; C10H14, 2) and [(η(5)-C5Me5)MCl(2-pcdpm)] (M = Rh, 3; Ir, 4) containing a new chelating ligand 4-(2-methoxypyridyl)-phenyldipyrromethene (2-pcdpm... |
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Identification of histamine receptor subtypes in skeletal myogenesis.
Mol. Med. Report. 11(4) , 2624-30, (2015) To date, conventional and/or novel histamine receptors (HRs) have not been investigated in mouse skeletal myogenesis. Therefore, the present study aimed to investigate the HR‑subtypes in skeletal myogenesis. The myogenesis of C2C12 skeletal myoblasts was eval... |
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A boron dipyrromethene-phthalocyanine pentad as an artificial photosynthetic model.
Chem. Commun. (Camb.) 49(29) , 2998-3000, (2013) A silicon(IV) phthalocyanine with two axial p-phenylene-linked boron dipyrromethene and monostyryl boron dipyrromethene moieties has been prepared. The resulting pentad absorbs strongly in most of the UV-visible region and serves as an artificial photosynthet... |
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High Efficacy of Combination Therapy Using PI3K/AKT Inhibitors with Androgen Deprivation in Prostate Cancer Preclinical Models.
Eur. Urol. 67 , 1177-85, (2015) The phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/AKT pathway is frequently activated during prostate cancer (PCa) progression through loss or mutation of the phosphatase and tensin homolog (PTEN) gene. Following the androgen receptor (AR) pathway, it... |
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Expression and activity of EGFR in human cutaneous melanoma cell lines and influence of vemurafenib on the EGFR pathway.
Target. Oncol. 10(1) , 77-84, (2015) Data regarding the expression of epidermal growth factor receptor (EGFR) in melanoma and its role in the tumor biology are conflicting. In BRAF V600-mutant melanomas, the expression of EGFR has been associated with acquired resistance to BRAF inhibitors. In t... |