2-亚氨基生物素
2-亚氨基生物素结构式
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常用名 | 2-亚氨基生物素 | 英文名 | 2-Iminobiotin |
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| CAS号 | 13395-35-2 | 分子量 | 243.326 | |
| 密度 | 1.6±0.1 g/cm3 | 沸点 | 477.3±55.0 °C at 760 mmHg | |
| 分子式 | C10H17N3O2S | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 242.5±31.5 °C |
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Influence of different classes of NO synthase inhibitors in the pig gastric fundus.
Naunyn Schmiedebergs Arch. Pharmacol. 356(4) , 488-94, (1997) The inhibitory potency of different classes of nitric oxide synthase (NOS) inhibitors (amino acid-based substances, guanidines, isothioureas, imidazoles and indazoles) versus peripheral neuronal NOS in the pig gastric fundus was investigated by studying their... |
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Intermolecular forces and energies between ligands and receptors.
Science 266(5183) , 257-9, (1994) The recognition mechanisms and dissociation pathways of the avidin-biotin complex and of actin monomers in actin filaments were investigated. The unbinding forces of discrete complexes of avidin or streptavidin with biotin analogs are proportional to the enth... |
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Effects of selective nitric oxide synthase inhibition on IGF-1, caspases and cytokines in a newborn piglet model of perinatal hypoxia-ischaemia.
Dev. Neurosci. 24(5) , 396-404, (2002) Selective inhibition of neuronal and inducible nitric oxide synthase (NOS) with 2-iminobiotin previously showed a reduction in brain cell injury. In the present study, we investigated the effects of 2-iminobiotin treatment on insulin-like growth factor-1 (IGF... |
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Pharmacological interventions in the newborn piglet in the first 24 h after hypoxia-ischemia. A hemodynamic and electrophysiological perspective.
Exp. Brain Res. 147(2) , 200-8, (2002) The purpose of this study was to investigate whether combined inhibition of neuronal and inducible nitric oxide synthase (NOS) by 2-iminobiotin, free radical scavenging by allopurinol, and non-protein-bound iron chelation with deferoxamine improved cerebral o... |
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Effects of hydrogen peroxide on the electrochemical decomposition of layer-by-layer thin films composed of 2-iminobiotin-labeled poly(ethyleneimine) and avidin.
J. Colloid. Interface Sci. 315(1) , 396-9, (2007) The effects of hydrogen peroxide on the electrochemical decomposition of layer-by-layer thin films composed of 2-iminobiotin-labeled poly(ethyleneimine) (ib-PEI) and avidin were studied. An ib-PEI/avidin thin film prepared on the surface of a platinum (Pt) fi... |
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Influence of architecture on the kinetic stability of molecular assemblies.
J. Am. Chem. Soc. 126(5) , 1318-9, (2004) The strength of a multimolecular system depends on the number of interactions that hold it together. Using dynamic force spectroscopy, we show how the kinetic stability of a system decreases as the number of molecular bonds is increased, as predicted by theor... |
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Binding of biotin to streptavidin stabilizes intersubunit salt bridges between Asp61 and His87 at low pH.
J. Mol. Biol. 274(5) , 776-800, (1997) The remarkable stability of the streptavidin tetramer towards subunit dissociation becomes even greater upon binding of biotin. At two equivalent extensive monomer-monomer interfaces, monomers tightly associate into dimers that in turn associate into the tetr... |
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Production of biologically active recombinant avidin in baculovirus-infected insect cells.
Protein Expr. Purif. 9(1) , 100-8, (1997) An efficient lepidopteran insect cell system was established for the expression of a recombinant form of chicken egg-white avidin. The gene product was obtained in both secreted and intracellular forms, and biologically active recombinant avidin was isolated ... |
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Selective and nonselective neuronal NOS inhibitors impair cognitive function in the three panel runway and passive avoidance tasks in rats.
Pharmacol. Biochem. Behav. 101(4) , 515-9, (2012) The aim of this study was to compare the effects of both neuronal NOS (nNOS) and inducible NOS (iNOS) inhibitor 2-iminobiotin, with the more selective nNOS inhibitor N(ω)-propyl-L-arginine (NPLA) and selective inducible NOS (iNOS) inhibitor aminoguanidine, on... |
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Crystallographic analysis of the pH-dependent binding of iminobiotin by streptavidin.
Protein Sci. 6(6) , 1338-42, (1997) Streptavidin binds 2'-iminobiotin in a pH-dependent fashion--affinity decreases as the pH is lowered. This property makes the purification of compounds conjugated to streptavidin or immobiotin possible under mild conditions by affinity chromatography. In orde... |