米非司酮
米非司酮结构式
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常用名 | 米非司酮 | 英文名 | Mifepristone |
|---|---|---|---|---|
| CAS号 | 84371-65-3 | 分子量 | 429.594 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 628.6±55.0 °C at 760 mmHg | |
| 分子式 | C29H35NO2 | 熔点 | 195-198°C | |
| MSDS | 中文版 美版 | 闪点 | 334.0±31.5 °C | |
| 符号 |
GHS08 |
信号词 | Danger |
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Potential role of hCG in apoptosis of human luteinized granulosa cells.
J. Reprod. Dev. 61(1) , 67-73, (2015) The corpus luteum (CL) forms after ovulation and acts as a temporary endocrine gland that produces progesterone (P4), a hormone that is essential for implantation and maintenance of pregnancy in mammals. In pregnant women, human chorionic gonadotropin (hCG) s... |
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Disturbances in production of progesterone and their implications in plant studies.
Steroids 96 , 153-63, (2015) Progesterone is a mammalian hormone that has also been discovered in plants but its physiological function in plants is not explained. Experiments using inhibitors of progesterone synthesis and binding would be useful in studies on the significance of this co... |
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Stress-Immune-Growth Interactions: Cortisol Modulates Suppressors of Cytokine Signaling and JAK/STAT Pathway in Rainbow Trout Liver.
PLoS ONE 10 , e0129299, (2015) Chronic stress is a major factor in the poor growth and immune performance of salmonids in aquaculture. However, the molecular mechanisms linking stress effects to growth and immune dysfunction is poorly understood. The suppressors of cytokine signaling (SOCS... |
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Evidence of an immunosuppressive effect of progesterone upon in vitro secretion of proinflammatory and prodegradative factors in a model of choriodecidual infection.
BJOG 122 , 1798-807, (2015) To evaluate whether progesterone (P4) is able to modulate the secretion of tumour necrosis factor α (TNF-α), interleukin-1β (IL-1β), IL-6, IL-8, IL-10 and matrix metalloproteinase-9 (MMP-9) after choriodecidual stimulation with lipopolysaccharide (LPS).Chorio... |
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Lack of presynaptic interaction between glucocorticoid and CB1 cannabinoid receptors in GABA- and glutamatergic terminals in the frontal cortex of laboratory rodents.
Neurochem. Int. 90 , 72-84, (2015) Corticosteroid and endocannabinoid actions converge on prefrontocortical circuits associated with neuropsychiatric illnesses. Corticosteroids can also modulate forebrain synapses by using endocannabinoid effector systems. Here, we determined whether corticost... |
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Classical and membrane-initiated estrogen signaling in an in vitro model of anterior hypothalamic kisspeptin neurons.
Endocrinology 156 , 2162-73, (2015) The neuropeptide kisspeptin is essential for sexual maturation and reproductive function. In particular, kisspeptin-expressing neurons in the anterior rostral periventricular area of the third ventricle are generally recognized as mediators of estrogen positi... |
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Ad 2.0: a novel recombineering platform for high-throughput generation of tailored adenoviruses.
Nucleic Acids Res. 43 , e50, (2015) Recombinant adenoviruses containing a double-stranded DNA genome of 26-45 kb were broadly explored in basic virology, for vaccination purposes, for treatment of tumors based on oncolytic virotherapy, or simply as a tool for efficient gene transfer. However, t... |
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Suppression of TDO-mediated tryptophan catabolism in glioblastoma cells by a steroid-responsive FKBP52-dependent pathway.
Glia 63(1) , 78-90, (2014) Tryptophan catabolism is increasingly recognized as a key and druggable molecular mechanism active in cancer, immune, and glioneural cells and involved in the modulation of antitumor immunity, autoimmunity and glioneural function. In addition to the pivotal r... |
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A transgenic zebrafish model for monitoring glucocorticoid receptor activity.
Genes. Brain. Behav. 0 , (2014) Gene regulation resulting from glucocorticoid receptor and glucocorticoid response element interactions is a hallmark feature of stress response signaling. Imbalanced glucocorticoid production and glucocorticoid receptor activity have been linked to socioecon... |
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Antihormonal agents as a strategy to improve the effect of chemo-radiation in cervical cancer: in vitro and in vivo study.
BMC Cancer 15 , 21, (2015) Over the past few years, the concurrent use of cisplatin-based chemotherapy and radiation therapy has dramatically improved the local response and increased overall survival in early-stage cervical cancer. However, for the advanced stages of the disease this ... |