FAUC 213
FAUC 213结构式
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常用名 | FAUC 213 | 英文名 | FAUC 213 |
|---|---|---|---|---|
| CAS号 | 337972-47-1 | 分子量 | 326.82300 | |
| 密度 | 1.28g/cm3 | 沸点 | N/A | |
| 分子式 | C18H19ClN4 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | N/A | |
| 符号 |
GHS07 |
信号词 | Warning |
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FAUC 213, a highly selective dopamine D4 receptor full antagonist, exhibits atypical antipsychotic properties in behavioural and neurochemical models of schizophrenia.
Psychopharmacology 175 , 7-17 , (2004) 2-[4-(4-Chlorophenyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine (FAUC 213) is a highly selective antagonist at the dopamine D(4) receptor subtype. It was designed as a derivative of two partial antagonists and has been proven to be a complete antagonist in ... |
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Rationally based efficacy tuning of selective dopamine d4 receptor ligands leading to the complete antagonist 2-[4-(4-chlorophenyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine (FAUC 213).
J. Med. Chem. 44 , 2691-2694 , (2001) Structure dependent efficacy studies in the field of selective D4 ligands led to the 2-aminomethyl substituted azaindole 2 (FAUC 213) that displayed strong D4 binding, high subtype selectivity, and complete antagonist properties in ligand-induced mitogenesis ... |
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