(S)-(-)-哌多洛尔
(S)-(-)-哌多洛尔结构式
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常用名 | (S)-(-)-哌多洛尔 | 英文名 | AGI-001 |
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| CAS号 | 26328-11-0 | 分子量 | 248.32100 | |
| 密度 | 1.152g/cm3 | 沸点 | 457.1ºC at 760mmHg | |
| 分子式 | C14H20N2O2 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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Loss of [125I]-pindolol binding to beta-adrenoceptors on rat nodose ganglion after chronic isoprenaline treatment.
J. Auton. Nerv. Syst. 60 , 12-16, (1996) The nodose ganglion contains the cell bodies of afferent nerves which convey predominantly sensory information from the viscera to the central nervous system (CNS). Autoradiographic studies show binding sites for beta-adrenoceptor ligands are present on secti... |
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Pindolol suppresses serotonergic neuronal activity and does not block the inhibition of serotonergic neurons produced by 8-hydroxy-2-(di-n-propylamino)tetralin in awake cats.
J. Pharmacol. Exp. Ther. 291 , 229, (1999) Clinical studies have shown that pindolol can enhance the effects of antidepressant drugs, presumably by acting as an antagonist at somatodendritic 5-hydroxytryptamine (5-HT)(1A) autoreceptors, which regulate the firing rate of central serotonergic neurons. T... |
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(-)-Pindolol increases dialysate concentrations of dopamine and noradrenaline, but not serotonin, in the frontal cortex of freely-moving rats.
Neuropharmacology 38 , 909, (1999) (-)-Pindolol (2.5-20.0 mg/kg, s.c.) markedly increased extracellular levels of dopamine (DA) and noradrenaline (NA) in single dialysate samples of the frontal cortex (FCX) of freely-moving rats. This action was specific inasmuch as serotonin (5-HT) levels wer... |
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The effect of ipsapirone and S(-)-pindolol on dopamine release in rat striatum and nucleus accumbens.
Brain Res. 842 , 445-451, (1999) Serotonin (5-hydroxytryptamine, 5-HT)(1A) receptor agonism and 5-HT(2A) receptor antagonism are components in the action of some of the recently developed antipsychotic drugs, e.g., clozapine and ziprasidone. However, studies of the role of 5-HT(1A) receptor ... |