腐草霉素
腐草霉素结构式
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常用名 | 腐草霉素 | 英文名 | Phleomycin |
|---|---|---|---|---|
| CAS号 | 11006-33-0 | 分子量 | 1324.38000 | |
| 密度 | 1.83 g/cm3 | 沸点 | 1718.8ºC at 760 mmHg | |
| 分子式 | C52H75N16O21S2 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 993.3ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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CRE recombinase-based positive-negative selection systems for genetic manipulation in Trypanosoma brucei.
Mol. Biochem. Parasitol. 157(1) , 73-82, (2008) The limited repertoire of drug-resistance markers imposes a serious obstacle to genetic manipulation of Trypanosoma brucei. Here we describe experiments with a fusion protein that allows positive selection for genome integration followed by CRE recombinase-me... |
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Copper(II).bleomycin, iron(III).bleomycin, and copper(II).phleomycin: comparative study of deoxyribonucleic acid binding.
Biochemistry 20 , 665-671, (1981) The kinetics and mechanism of binding of Cu-(II).bleomycin, Fe(III).bleomycin, and Cu(II).phleomycin to DNA were studied by using fluorometry, equilibrium dialysis, electric dichroism, and temperature-jump and stopped-flow spectrophotometry. The affinity of C... |
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Sulphydryl-mediated DNA breakage by phlemomycin in Escherichia coli.
Mutat. Res. 42 , 181-190, (1977) Sulphydryl-mediated DNA breakage, which is induced by the antibiotic phleomycin in vitro, has been found to contribute significantly to the DNA damage produced by phleomycin in Escherichia coli. The effect of pleomycin was inhibited in vivo, as in vitro, by c... |
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Bleomycin and X-ray-hypersensitive Chinese hamster ovary cell mutants: genetic analysis and cross-resistance to neocarzinostatin.
Mutat. Res. 193 , 157-165, (1988) We have previously reported the isolation of 3 mutants of Chinese hamster ovary cells which exhibit hypersensitivity to bleomycin. 2 mutants were isolated on the basis of bleomycin-sensitivity [designated BLM-1 and BLM-2, Robson et al., Cancer Res., 45 (1985)... |
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A Saccharomyces cerevisiae phleomycin-sensitive mutant, ph140, is defective in the RAD6 DNA repair gene.
Can. J. Microbiol. 42 , 1263-1266, (1996) The antibiotic bleomycin is used as an anticancer agent for treating a variety of tumours. The antitumour effect of bleomycin is related to its ability to produce lesions such as apurinic/apyrimidinic sites and single- and double-strand breaks in the cellular... |
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Extending the Schizosaccharomyces pombe molecular genetic toolbox.
PLoS ONE 9(5) , e97683, (2014) Targeted alteration of the genome lies at the heart of the exploitation of S. pombe as a model system. The rate of analysis is often determined by the efficiency with which a target locus can be manipulated. For most loci this is not a problem, however for so... |