buprenorphine b-d-glucuronide
buprenorphine b-d-glucuronide结构式
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常用名 | buprenorphine b-d-glucuronide | 英文名 | buprenorphine b-d-glucuronide |
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| CAS号 | 101224-22-0 | 分子量 | 643.76400 | |
| 密度 | 1.43g/cm3 | 沸点 | N/A | |
| 分子式 | C35H49NO10 | 熔点 | N/A | |
| MSDS | N/A | 闪点 | 9 °C | |
| 符号 |
GHS02, GHS06, GHS08 |
信号词 | Danger |
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Buprenorphine and major metabolites in blood specimens collected for drug analysis in law enforcement purposes.
Forensic Sci. Int. 195(1-3) , 73-7, (2010) A liquid chromatographic/electrospray ionization tandem mass spectrometric method for the quantification of buprenorphine (BUP), norbuprenorphine (NBUP), buprenorphine-3-beta-D-glucuronide (BUPG) and norbuprenorphine-3-beta-D-glucuronide (NBUPG) in serum samp... |
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Interactions between buprenorphine and the protease inhibitors darunavir-ritonavir and fosamprenavir-ritonavir.
Clin. Infect. Dis. 54(3) , 414-23, (2012) This study examined drug interactions between buprenorphine, a partial opioid agonist used for opioid dependence treatment and pain management, and the protease inhibitors (PIs) darunavir-ritonavir and fosamprenavir-ritonavir.The pharmacokinetics of buprenorp... |
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Simultaneous determination of buprenorphine, norbuprenorphine, and buprenorphine-glucuronide in plasma by liquid chromatography-tandem mass spectrometry.
J. Chromatogr. B. Biomed. Sci. Appl. 754(2) , 447-59, (2001) For the first time, an LC-MS-MS method has been developed for the simultaneous analysis of buprenorphine (BUP), norbuprenorphine (NBUP), and buprenorphine-glucuronide (BUPG) in plasma. Analytes were isolated from plasma by C18 SPE and separated by gradient RP... |
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Effect of rifampin and nelfinavir on the metabolism of methadone and buprenorphine in primary cultures of human hepatocytes.
Drug Metab. Dispos. 37(12) , 2323-9, (2009) We tested the hypothesis that primary cultures of human hepatocytes could predict potential drug interactions with methadone and buprenorphine. Hepatocytes (five donors) were preincubated with dimethyl sulfoxide (DMSO) (vehicle), rifampin, or nelfinavir befor... |
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Liquid chromatographic/electrospray ionization tandem mass spectrometric analysis for the quantification of buprenorphine, norbuprenorphine, buprenorphine-3-beta-D-glucuronide and norbuprenorphine-3-beta-D-glucuronide in human plasma.
J. Mass Spectrom. 40(1) , 70-4, (2005) A liquid chromatographic/electrospray ionization tandem mass spectrometric method for the quantification of the synthetic opiate buprenorphine (BUP), norbuprenorphine (NBUP), buprenorphine-3-beta-D-glucuronide (BUP-3-G) and norbuprenorphine-3-beta-D-glucuroni... |
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The in vivo glucuronidation of buprenorphine and norbuprenorphine determined by liquid chromatography-electrospray ionization-tandem mass spectrometry.
Ther. Drug Monit. 28(2) , 245-51, (2006) The opioid partial agonist medication, buprenorphine (BUP), and its primary metabolite, norbuprenorphine (NBUP), are extensively glucuronidated. Sensitive analytical methods that include determination of buprenorphine-3-glucuronide (BUPG) and norbuprenorphine... |
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Buprenorphine disposition in patients with renal impairment: single and continuous dosing, with special reference to metabolites.
Br. J. Anaesth. 64(3) , 276-82, (1990) The disposition of buprenorphine has been studied in two patient groups to assess the influence of impaired renal function on the metabolism of buprenorphine and two of its metabolites, buprenorphine-3-glucuronide (B3G) and norbuprenorphine (NorB). A single i... |
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Rapid quantification of buprenorphine-glucuronide and norbuprenorphine-glucuronide in human urine by LC-MS-MS.
J. Anal. Toxicol. 31(4) , 214-9, (2007) A liquid chromatography-tandem mass spectrometry (LC-MS-MS) method was developed and validated for the determination of buprenorphine-glucuronide (BUP-G) and norbuprenorphine-glucuronide (NBUP-G) in human urine. The method included a dilution step followed by... |
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Radioimmunoassay of buprenorphine with iodine label: analysis of buprenorphine and metabolites in human plasma.
Ann. Clin. Biochem. 23 ( Pt 1) , 47-53, (1986) Quantitative analysis of potent opiate drugs in plasma by radioimmunoassay is potentially inaccurate because of the occurrence of cross-reacting metabolites. This paper describes the chemical synthesis of buprenorphine-3-O-glucuronide, a metabolite of bupreno... |
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Hydrolysis of conjugated metabolites of buprenorphine. I. The quantitative enzymatic hydrolysis of buprenorphine-3-beta-D-glucuronide in human urine.
J. Anal. Toxicol. 25(7) , 589-93, (2001) Buprenorphine, which is a powerful analgesic, a substitution drug for opioids widely used in Europe, and a promising new drug currently undergoing clinical trials in the treatment of opioid dependence in the U.S., is excreted in human urine mainly as glucuron... |