N-琥珀酰-L-丙氨酰-L-丙氨酰-L-丙氨酸
N-琥珀酰-L-丙氨酰-L-丙氨酰-L-丙氨酸结构式
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常用名 | N-琥珀酰-L-丙氨酰-L-丙氨酰-L-丙氨酸 | 英文名 | Suc-Ala-Ala-Ala-pNA |
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| CAS号 | 52299-14-6 | 分子量 | 451.43 | |
| 密度 | 1.37 g/cm3 | 沸点 | 923.5ºC at 760 mmHg | |
| 分子式 | C19H25N5O8 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 512.3ºC |
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A new Kunitz-type plasmin inhibitor from scorpion venom.
Toxicon 106 , 7-13, (2015) Kunitz-type peptides from venomous animals are an important source of lead drug candidates towards human plasmin, a target of protease-associated diseases. However, no Kunitz-type plasmin inhibitor from venomous scorpion has been characterized. Here, we first... |
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SjAPI, the first functionally characterized Ascaris-type protease inhibitor from animal venoms.
PLoS ONE 8(3) , e57529, (2013) Serine protease inhibitors act as modulators of serine proteases, playing important roles in protecting animal toxin peptides from degradation. However, all known serine protease inhibitors discovered thus far from animal venom belong to the Kunitz-type subfa... |
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Purification, kinetical and molecular characterizations of a serine collagenolytic protease from greenshore crag (Carcinus maenas) digestive gland.
Comp. Biochem. Physiol. B Biochem. Mol. Biol. 115(1) , 87-95, (1996) A serine collagenolytic protease was purified from a water soluble fraction of greenshore crab digestive gland by acidic precipitation, gel filtration on a Sephadex G-50 column, ion-exchange chromatography on a Fractogel TSK DEAE column, immobilized metal ion... |
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Characterization of metalloelastase-like activity from the plasma of a patient with Tangier disease.
Biol. Chem. Hoppe-Seyler 372 , 1057-1064, (1991) An enzymatic activity with releases p-nitroaniline from 3-carboxypropionyl-trialanine p-nitroanilide (Suc[Ala]3NA) was characterized in blood plasma of patients with Tangier disease. This activity results from the sequential action of a metalloendopeptidase (... |
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Determination and characterization of succinyl tri-alanine p-nitroanilide hydrolyzing metalloendopeptidase in serum.
Enzyme 37(4) , 202-7, (1987) Serum succinyl (Ala)3-p-nitroanilide hydrolyzing elastase-like activity which elevates in patients with obstructive jaundice, is due to the joint action of two enzymes: first, succinyl (Ala)3-p-nitroanilide is cleaved to succinyl (Ala)2 and Ala-p-nitroanilide... |
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Determination of elastase inhibitory activity of alpha 1-proteinase inhibitor and bronchial antileukoprotease: different results using insoluble elastin or synthetic low molecular weight substrates.
Scand. J. Clin. Lab. Invest. 47(4) , 405-10, (1987) We have determined the effect of two elastase-specific synthetic low molecular weight substrates, L-pyroglutamylprolylvaline-paranitroanilide and succinyltrialanyl-paranitroanilide, together with insoluble elastin-fluorescein, on the determination of the neut... |
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Inhibition of leucocyte elastase by heparin and its derivatives.
Biochem. J. 252(2) , 515-9, (1988) Leucocyte proteinases, e.g. leucocyte elastase and cathepsin G, are inhibited by heparin. The activities of pig pancreatic and Pseudomonas aeruginosa elastases are unaffected by this polysaccharide. Heparin derivatives of known Mr and degree of sulphation wer... |
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Phagocyte enzymes in bronchoalveolar lavage from patients with pulmonary sarcoidosis and collagen vascular disorders.
Eur. Respir. J. 3(3) , 249-56, (1990) The balance between proteases and antiproteases in the lower respiratory tract is believed to play a role in the outcome of interstitial lung diseases. In this cross-sectional study, we measure several phagocyte derived enzymes, namely plasminogen activator, ... |
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Elastase-like protease and elastolytic activities expressed in cultured dermal fibroblasts derived from lesional skin of patients with pseudoxanthoma elasticum, actinic elastosis, and cutis laxa.
Clin. Chim. Acta 176(2) , 219-24, (1988)
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Administration of elastase blocks the formation of fragmented elastic fibers in aorta of rabbit.
Artery 16(6) , 293-311, (1989) Fragmented elastic fibers are known to be associated with atherosclerotic lesions, angitis and age-related changes of the vessel wall. We produced fragmented elastic fibers in the thoracic aorta by immunizing rabbits with elastin peptides. Fragmented elastic ... |