5-五羟色胺 马来酸盐
5-五羟色胺 马来酸盐结构式
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常用名 | 5-五羟色胺 马来酸盐 | 英文名 | Serotonin hydrogen maleate |
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| CAS号 | 18525-25-2 | 分子量 | 292.28700 | |
| 密度 | N/A | 沸点 | 416.1ºC at 760mmHg | |
| 分子式 | C14H16N2O5 | 熔点 | 154-158ºC (dec.) | |
| MSDS | 中文版 美版 | 闪点 | 205.4ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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Nest building is impaired in the Ts65Dn mouse model of Down syndrome and rescued by blocking 5HT2a receptors.
Neurobiol. Learn. Mem. 116 , 162-71, (2014) Down syndrome (DS) has an incidence of about 1/700 births, and is therefore the most common cause of cognitive and behavioral impairments in children. Recent studies on mouse models of DS indicate that a number of pharmacotherapies could be beneficial for res... |
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Permeation of Dopamine Sulfate through the Blood-Brain Barrier.
PLoS ONE 10 , e0133904, (2015) Dopamine sulfate (DA-3- and DA-4-S) have been determined in the human brain, but it is unclear whether they are locally formed in the central nervous system (CNS), or transported into the CNS from peripheral sources. In the current study, permeation of the bl... |
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Kinetics of serotonin oxidation by heme-Aβ relevant to Alzheimer's disease.
J. Biol. Inorg. Chem. 19(8) , 1355-65, (2014) Serotonin (5-HT) is an essential neurotransmitter for cognitive functions and formation of new memories. A deficit in 5-HT dependent neuronal activity is somewhat specific for Alzheimer's disease. Metal-mediated oxidative degradation of neurotransmitters by A... |
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Seasonal postembryonic maturation of the diurnal rhythm of serotonin in the chicken pineal gland.
Chronobiol. Int. 32(1) , 59-70, (2015) Previously, we have demonstrated the postembryonic development of chicken (Gallus gallus domesticus L.) pineal gland functions expressed as changes in melatonin (MEL) biosynthesis. Pineal concentrations of MEL and its precursor serotonin (5-HT) were shown to ... |
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Comparison of centrally injected tryptophan-related substances inducing sedation in acute isolation stress-induced neonatal chicks.
Pharmacol. Biochem. Behav. 129 , 1-6, (2015) In the present study, we first focused on the function of l-tryptophan (TRP) metabolites which are synthesized in different metabolic pathways, namely, the kynurenine (KYN) pathway and serotonin (5-HT) pathway during an acute isolation stress. When l-TRP meta... |
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Antidepressant-like effect of bright light is potentiated by l-serine administration in a mouse model of seasonal affective disorder.
Brain Res. Bull. 118 , 25-33, (2015) Bright light therapy is used as the primary treatment for seasonal affective disorder; however, the mechanisms underlying its antidepressant effect are not fully understood. Previously, we found that C57BL/6J mice exhibit increased depression-like behavior du... |
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Orally administrated dipeptide Ser-Tyr efficiently stimulates noradrenergic turnover in the mouse brain.
Biosci. Biotechnol. Biochem. 79 , 1542-7, (2015) In this study, we examined the effect of orally administrated dipeptides containing Tyr (Y) on the metabolism of catecholamines in mouse brains. We found that among eight synthetic dipeptides whose sequences are present frequently in soy proteins, Ser-Tyr (SY... |
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The effect of curcumin on the brain-gut axis in rat model of irritable bowel syndrome: involvement of 5-HT-dependent signaling.
Metab. Brain Dis. 30(1) , 47-55, (2015) Irritable bowel syndrome (IBS) is induced by dysfunction of central nervous and peripheral intestinal systems, which affects an estimated 10-15% population worldwide annually. Stress-related psychiatric disorders including depression and anxiety are often com... |
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Time-dependent effects of L-tryptophan administration on urinary excretion of L-tryptophan metabolites.
J. Nutr. Sci. Vitaminol. 60(4) , 255-60, (2014) We have previously reported that dietary supplementation with up to 5.0 g/d of L-tryptophan (L-Trp) for 21 d has no adverse effects, judging from the levels of general blood variables, in healthy women. We performed a randomized, double-blind, placebo-control... |
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Simultaneous quantification of seven hippocampal neurotransmitters in depression mice by LC-MS/MS.
J. Neurosci. Methods 229 , 8-14, (2014) There is no method available to simultaneously detect GABA, Glu, Epi, NE, DA, 5-HT and 5-HIAA in mouse hippocampus.A rapid and sensitive LC-MS/MS method has been developed for simultaneously measuring seven neurotransmitters in mouse hippocampus. The analytes... |