5α,6α-epoxy Cholestanol
5α,6α-epoxy Cholestanol结构式
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常用名 | 5α,6α-epoxy Cholestanol | 英文名 | Cholesterol-5α,6α-epoxide |
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| CAS号 | 1250-95-9 | 分子量 | 402.65300 | |
| 密度 | 1.04g/cm3 | 沸点 | 497.7ºC at 760mmHg | |
| 分子式 | C27H46O2 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | 200.9ºC |
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Oxysterols: modulators of cholesterol metabolism and other processes.
Physiol. Rev. 80 , 361-554, (2000) Oxygenated derivatives of cholesterol (oxysterols) present a remarkably diverse profile of biological activities, including effects on sphingolipid metabolism, platelet aggregation, apoptosis, and protein prenylation. The most notable oxysterol activities cen... |
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Oxysterols as non-genomic regulators of cholesterol homeostasis.
Trends Endocrinol. Metab. 23 , 99-106, (2012) Tight regulation of cellular and plasma cholesterol is crucial to proper cellular functioning because excess free cholesterol is toxic to cells and is associated with atherosclerosis and heart disease. Cellular cholesterol homeostasis is regulated by enzymati... |
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Surprising unreactivity of cholesterol-5,6-epoxides towards nucleophiles.
J. Lipid Res. 53(4) , 718-25, (2012) We recently established that drugs used for the treatment and the prophylaxis of breast cancers, such as tamoxifen, were potent inhibitors of cholesterol-5,6-epoxide hydrolase (ChEH), which led to the accumulation of 5,6α-epoxy-cholesterol (5,6α-EC) and 5,6β-... |
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Alcohol enhances oxysterol-induced apoptosis in human endothelial cells by a calcium-dependent mechanism.
Arterioscler. Thromb. Vasc. Biol. 21 , 439-44, (2001) Controversy exists about the net effect of alcohol on atherogenesis. A protective effect is assumed, especially from the tannins and phenolic compounds in red wine, owing to their inhibition of low density lipoprotein (LDL) oxidation. However, increased ather... |
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Formation of biologically active oxysterols during ozonolysis of cholesterol present in lung surfactant.
J. Biol. Chem. 279(25) , 26331-8, (2004) Exposure of the lung to concentrations of ozone found in ambient air is known to cause toxicity to the epithelial cells of the lung. Because of the chemical reactivity of ozone, it likely reacts with target molecules in pulmonary surfactant, a lipid-rich mate... |
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Comparative study of the cytotoxicity and apoptosis-inducing potential of commonly occurring oxysterols.
Cell Biol. Toxicol. 17(2) , 127-37, (2001) The cytotoxicity of the oxysterols 25-hydroxycholesterol, 7beta-hydroxycholesterol, cholesterol-5alpha,6alphaepoxide, cholesterol-5beta,6beta-epoxide, 19-hydroxycholesterol and 7-ketocholesterol was examined in U937 cells, a human monocytic blood cell line. 7... |
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The role of the mitochondria in apoptosis induced by 7beta-hydroxycholesterol and cholesterol-5beta,6beta-epoxide.
Br. J. Nutr. 94(4) , 519-25, (2005) Oxysterols are oxygenated derivatives of cholesterol that may be formed endogenously or absorbed from the diet. Significant amounts of oxysterols have frequently been identified in foods of animal origin, in particular highly processed foods. To date, oxyster... |
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An excess concentration of oxysterols in the plasma is cytotoxic to cultured endothelial cells.
Atherosclerosis 149(1) , 191-7, (2000) To test if there is an excess concentration of oxysterols in the plasma of the patients with cardiovascular disease, we analyzed the oxysterol content in the plasma from 105 cardiac catheterized patients with angina and 80+/-8% stenosis in their coronary arte... |
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Inhibition by cholesterol oxides of NO release from human vascular endothelial cells.
Arterioscler. Thromb. Vasc. Biol. 18(7) , 1054-60, (1998) Recent studies have demonstrated that, unlike cholesterol, cholesterol oxidized at position 7 can reduce the maximal endothelium-dependent relaxation of isolated rabbit aortas (Circulation. 1997;95:723-731). The aim of the current study was to determine wheth... |
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Oxidized cholesterol in the diet is a source of oxidized lipoproteins in human serum.
J. Lipid Res. 44(4) , 705-15, (2003) The aim of this study was to determine in humans whether oxidized cholesterol in the diet is absorbed and contributes to the pool of oxidized lipids in circulating lipoproteins. When a meal containing 400 mg cholestan-5alpha,6alpha-epoxy-3beta-ol (alpha-epoxy... |