1,3-二丙基-8-环戊基黄嘌呤
1,3-二丙基-8-环戊基黄嘌呤结构式
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常用名 | 1,3-二丙基-8-环戊基黄嘌呤 | 英文名 | DPCPX |
|---|---|---|---|---|
| CAS号 | 102146-07-6 | 分子量 | 304.38700 | |
| 密度 | 1.195g/cm3 | 沸点 | 535.1ºC at 760mmHg | |
| 分子式 | C16H24N4O2 | 熔点 | 178°C | |
| MSDS | 中文版 美版 | 闪点 | 277.4ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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Regulatory T cell-derived adenosine induces dendritic cell migration through the Epac-Rap1 pathway.
J. Immunol. 194(8) , 3735-44, (2015) Dendritic cells (DC) are one target for immune suppression by regulatory T cells (Treg), because their interaction results in reduced T cell stimulatory capacity and secretion of inhibitory cytokines in DC. We show that DC in the presence of Treg are more mob... |
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Increased tonic cannabinoid CB1R activity and brain region-specific desensitization of CB1R Gi/o signaling axis in mice with global genetic knockout of monoacylglycerol lipase.
Eur. J. Pharm. Sci. 77 , 180-8, (2015) In mammalian brain, monoacylglycerol lipase (MAGL) is the primary enzyme responsible for terminating signaling function of the endocannabinoid 2-arachidonoylglycerol (2-AG). Previous in vivo studies with mice indicate that both genetic and chronic pharmacolog... |
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Endothelial dysfunction impairs vascular neurotransmission in tail arteries.
Neurochem. Int. 80 , 7-13, (2015) The present study intends to clarify if endothelium dysfunction impairs vascular sympathetic neurotransmission. Electrically-evoked tritium overflow (100 pulses/5 Hz) was evaluated in arteries (intact and denuded) or exhibiting some degree of endothelium dysf... |
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Caffeine exposure alters cardiac gene expression in embryonic cardiomyocytes.
Am. J. Physiol. Regul. Integr. Comp. Physiol. 307(12) , R1471-87, (2014) Previous studies demonstrated that in utero caffeine treatment at embryonic day (E) 8.5 alters DNA methylation patterns, gene expression, and cardiac function in adult mice. To provide insight into the mechanisms, we examined cardiac gene and microRNA (miRNA)... |
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Adenosine A1 receptor stimulation reduces D1 receptor-mediated GABAergic transmission from striato-nigral terminals and attenuates l-DOPA-induced dyskinesia in dopamine-denervated mice
Exp. Neurol. 261 , 733-43, (2014) γ-Aminobutyric acid A receptor (GABAAR)-mediated postsynaptic currents were recorded in brain slices from substantia nigra pars reticulate neurons. The selective adenosine A1 receptor (A1R) antagonist, 8-cyclopentyl-1,3-dipropylxanthine (DPCPX), increased the... |
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Chaperoning of the A1-adenosine receptor by endogenous adenosine - an extension of the retaliatory metabolite concept.
Mol. Pharmacol. 87(1) , 39-51, (2015) Cell-permeable orthosteric ligands can assist folding of G protein-coupled receptors in the endoplasmic reticulum (ER); this pharmacochaperoning translates into increased cell surface levels of receptors. Here we used a folding-defective mutant of human A1-ad... |
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A Positive Allosteric Modulator of the Adenosine A1 Receptor Selectively Inhibits Primary Afferent Synaptic Transmission in a Neuropathic Pain Model.
Mol. Pharmacol. 88 , 460-8, (2015) In the spinal cord and periphery, adenosine inhibits neuronal activity through activation of the adenosine A1 receptor (A1R), resulting in antinociception and highlighting the potential of therapeutically targeting the receptor in the treatment of neuropathic... |
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Differential Effect of Neuropeptides on Excitatory Synaptic Transmission in Human Epileptic Hippocampus.
J. Neurosci. 35 , 9622-31, (2015) Development of novel disease-modifying treatment strategies for neurological disorders, which at present have no cure, represents a major challenge for today's neurology. Translation of findings from animal models to humans represents an unresolved gap in mos... |
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Adenosinergic regulation of binge-like ethanol drinking and associated locomotor effects in male C57BL/6J mice.
Pharmacol. Biochem. Behav. 135 , 83-9, (2015) We recently observed that the addition of caffeine (a nonselective adenosine receptor antagonist) to a 20% ethanol solution significantly altered the intoxication profile of male C57BL/6J (B6) mice induced by voluntary binge-like consumption in the 'Drinking-... |
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Enzymatic conversion of ATP to adenosine contributes to ATP-induced inhibition of glutamate release in rat medullary dorsal horn neurons.
Neuropharmacology 93 , 94-102, (2015) Purine nucleotides, such as ATP and ADP, activate ionotropic P2X and metabotropic P2Y receptors to regulate neurotransmitter release in the peripheral as well as central nervous system. Here we report another type of ATP-induced presynaptic modulation of glut... |