3,5-二碘-L-甲状腺素
3,5-二碘-L-甲状腺素结构式
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常用名 | 3,5-二碘-L-甲状腺素 | 英文名 | 3,5-Diiodo-L-thyronine |
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| CAS号 | 1041-01-6 | 分子量 | 525.077 | |
| 密度 | 2.1±0.1 g/cm3 | 沸点 | 559.4±50.0 °C at 760 mmHg | |
| 分子式 | C15H13I2NO4 | 熔点 | 255-260 °C (dec.) | |
| MSDS | 中文版 美版 | 闪点 | 292.1±30.1 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Administration of 3,5-diiodothyronine (3,5-T2) causes central hypothyroidism and stimulates thyroid-sensitive tissues.
J. Endocrinol. 221(3) , 415-27, (2014) In general, 3,5-diiodothyronine (3,5-T2) increases the resting metabolic rate and oxygen consumption, exerting short-term beneficial metabolic effects on rats subjected to a high-fat diet. Our aim was to evaluate the effects of chronic 3,5-T2 administration o... |
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In Vitro, Ex Vivo, and In Vivo Determination of Thyroid Hormone Modulating Activity of Benzothiazoles.
Toxicol. Sci. 146 , 254-64, (2015) As in vitro assays are increasingly used to screen chemicals for their potential to produce endocrine disrupting adverse effects, it is important to understand their predictive capacity. The potential for a set of 6 benzothiazoles to affect endpoints related ... |
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Ion pair hollow fiber liquid-liquid-liquid microextraction combined with capillary electrophoresis-ultraviolet detection for the determination of thyroid hormones in human serum.
J. Chromatogr. A. 1356 , 23-31, (2014) In this study, a novel, inexpensive, sensitive and selective analytical method that combines ion pair hollow fiber liquid-liquid-liquid microextraction (IP-HF-LLLME) with capillary electrophoresis-ultraviolet detection (CE-UV) was developed for the simultaneo... |
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Acute effects of thyroid hormone analogs on sodium currents in neonatal rat myocytes.
J. Mol. Cell. Cardiol. 31 , 881-93, (1999) We previously reported that T3(3,3',5-triiodo-L-thyronine) acutely increases sodium currents (INa) in neonatal rat myocytes. Here we compare the effects of several thyroid hormone analogs, including T4(3,3',5,5'-tetraiodo-L-thyronine), rT3(3,3',5'-triiodo-L-t... |
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3,5-Diiodothyronine in vivo maintains euthyroidal expression of type 2 iodothyronine deiodinase, growth hormone, and thyroid hormone receptor beta1 in the killifish.
Am. J. Physiol. Regul. Integr. Comp. Physiol. 293(2) , R877-83, (2007) Until recently, 3,5-diiodothyronine (3,5-T(2)) has been considered an inactive by-product of triiodothyronine (T(3)) deiodination. However, studies from several laboratories have shown that 3,5-T(2) has specific, nongenomic effects on mitochondrial oxidative ... |
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Thyroid hormone interactions with DMPC bilayers. A molecular dynamics study.
J. Phys. Chem. B 113(40) , 13357-64, (2009) The structure and dynamics of thyroxine (T4), distal and proximal conformers of 3',3,5-triiodo-l-thyronine (T3d and T3p), and 3,5-diiodo-l-thyronine (T2) upon interaction with DMPC membranes were analyzed by means of molecular dynamics simulations. The locati... |
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Role of thyrotropin in metabolism of thyroid hormones in nonthyroidal tissues.
Metab. Clin. Exp. 55(6) , 748-50, (2006) T(4) conversion into T(3) in peripheral tissues is the major source of circulating T(3). However, the exact mechanism of this process is ill defined. Several in vitro studies have demonstrated that thyrotropin facilitates deiodination of T(4) into T(3) in liv... |
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Nonthyrotoxic prevention of diet-induced insulin resistance by 3,5-diiodo-L-thyronine in rats.
Diabetes 60(11) , 2730-9, (2011) High-fat diets (HFDs) are known to induce insulin resistance. Previously, we showed that 3,5-diiodothyronine (T2), concomitantly administered to rats on a 4-week HFD, prevented gain in body weight and adipose mass. Here we investigated whether and how T2 prev... |
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Direct effects of iodothyronines on excess fat storage in rat hepatocytes
J. Hepatol. 54(6) , 1230-6, (2011) Background & Aims Previous studies have demonstrated that 3,5-l-diiodothyronine (T2) is able to prevent lipid accumulation in the liver of rats fed a high-fat diet. Whether this effect is due to a direct action of T2 on the liver has not been elucidated. In t... |
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3,5-Diiodo-L-thyronine rapidly enhances mitochondrial fatty acid oxidation rate and thermogenesis in rat skeletal muscle: AMP-activated protein kinase involvement.
Am. J. Physiol. Endocrinol. Metab. 296(3) , E497-502, (2009) Triiodothyronine regulates energy metabolism and thermogenesis. Among triiodothyronine derivatives, 3,5-diiodo-l-thyronine (T(2)) has been shown to exert marked effects on energy metabolism by acting mainly at the mitochondrial level. Here we investigated the... |