帽柱木碱盐酸盐
帽柱木碱盐酸盐结构式
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常用名 | 帽柱木碱盐酸盐 | 英文名 | Mitragynine |
|---|---|---|---|---|
| CAS号 | 4098-40-2 | 分子量 | 398.495 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 560.3±50.0 °C at 760 mmHg | |
| 分子式 | C29H33N5O11 | 熔点 | 92-95ºC | |
| MSDS | N/A | 闪点 | 292.7±30.1 °C | |
| 符号 |
GHS02, GHS06, GHS08 |
信号词 | Danger |
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A drug fatality involving Kratom.
J. Forensic Sci. 58 Suppl 1 , S278-9, (2013) A 17-year-old white man who showed no obvious signs of trauma was found unresponsive in bed and was pronounced dead at the scene. The decedent had a documented history of heroin abuse and chronic back pain and reportedly self-medicated with Kratom (mitragynin... |
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Orally active opioid compounds from a non-poppy source.
J. Med. Chem. 56(12) , 4840-8, (2013) The basic science and clinical use of morphine and other "opioid" drugs are based almost exclusively on the extracts or analogues of compounds isolated from a single source, the opium poppy (Papaver somniferum). However, it now appears that biological diversi... |
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Determination of mitragynine in plasma with solid-phase extraction and rapid HPLC-UV analysis, and its application to a pharmacokinetic study in rat.
Anal. Bioanal. Chem 397(5) , 2023-30, (2010) A new solid phase extraction method for rapid high performance liquid chromatography-UV determination of mitragynine in plasma has been developed. Optimal separation was achieved with an isocratic mobile phase consisting of acetonitrile-ammonium acetate buffe... |
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A simple HPLC-DAD method for the detection and quantification of psychotropic mitragynine in Mitragyna speciosa (ketum) and its products for the application in forensic investigation.
Forensic Sci. Int. 226(1-3) , 183-7, (2013) Mitragyna speciosa, a native plant of Thailand and Malaysia known as 'ketum', is a plant of considerable interest. It exhibits strong antinociceptive effect and yet, acts like a psychostimulant. Due to the affordability and its ease of availability, the abuse... |
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Total syntheses of mitragynine, paynantheine and speciogynine via an enantioselective thiourea-catalysed Pictet-Spengler reaction.
Chem. Commun. (Camb.) 48(100) , 12243-5, (2012) The pharmacologically interesting indole alkaloids (-)-mitragynine, (+)-paynantheine and (+)-speciogynine were synthesised in nine steps from 4-methoxytryptamine by a route featuring (i) an enantioselective thiourea-catalysed Pictet-Spengler reaction, providi... |
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Analysis of mitragynine and metabolites in human urine for detecting the use of the psychoactive plant kratom.
J. Anal. Toxicol. 36(9) , 616-25, (2012) The leaves of the South Asian plant kratom are described as having stimulating effects at low doses, and opiate-like analgesic and euphoric effects at high doses. A long history of use and abuse has led to the classification of kratom as a controlled substanc... |
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Limitation of mitragynine biosynthesis in Mitragyna speciosa (Roxb.) Korth. through tryptamine availability.
Z. Naturforsch., C, J. Biosci. 68(9-10) , 394-405, (2013) Metabolite profiles of Mitragyna speciosa were determined by means of 1H NMR-based and HPLC-based analyses. The results indicated that high contents of secologanin, caffeic acid, gallic acid, epigallocatechin, and mitragynine were accumulated in leaves. In M.... |
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In vitro evaluation of cytochrome P450 induction and the inhibition potential of mitragynine, a stimulant alkaloid.
Toxicol. In Vitro 27(2) , 812-24, (2013) CYP450 enzymes are key determinants in drug toxicities, reduced pharmacological effect and adverse drug reactions. Mitragynine, an euphoric compound was evaluated for its effects on the expression of mRNAs encoding CYP1A2, CYP2D6 and CYP3A4 and protein expres... |
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A coincidence of addiction to "Kratom" and severe primary hypothyroidism.
J. Addict. Med. 5(4) , 300-1, (2011) Here we present a case of a coincidence of addiction to "Kratom" (botanically known as Mitragyna speciosa Korth) and developed severe primary hypothyroidism. We are discussing a possibility that high dose of indole alkaloid mitragynine (the major alkaloid ide... |
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Methyl jasmonate and yeast extract stimulate mitragynine production in Mitragyna speciosa (Roxb.) Korth. shoot culture.
Biotechnol. Lett. 34(10) , 1945-50, (2012) Mitragynine is a pharmacologically-active terpenoid indole alkaloid found in Mitragyna speciosa leaves. Treatment with methyl jasmonate (10 μM) for 24 h and yeast extract (0.1 mg/ml) for 12 h were the optimum conditions of elicitation of mitragynine accumulat... |