N-(6-氨基己基)-1-萘磺酰胺盐酸盐
N-(6-氨基己基)-1-萘磺酰胺盐酸盐结构式
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常用名 | N-(6-氨基己基)-1-萘磺酰胺盐酸盐 | 英文名 | W-5 hydrochloride |
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| CAS号 | 61714-25-8 | 分子量 | 342.884 | |
| 密度 | 1.176g/cm3 | 沸点 | 493.2ºC at 760mmHg | |
| 分子式 | C16H23ClN2O2S | 熔点 | 150-152ºC | |
| MSDS | 中文版 美版 | 闪点 | 252.1ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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Muscarinic receptor-mediated excitation of rat intracardiac ganglion neurons.
Neuropharmacology 95 , 395-404, (2015) Modulation of the membrane excitability of rat parasympathetic intracardiac ganglion neurons by muscarinic receptors was studied using an amphotericin B-perforated patch-clamp recording configuration. Activation of muscarinic receptors by oxotremorine-M (OxoM... |
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Essential role of Ca2+/calmodulin in Early Endosome Antigen-1 localization.
Mol. Biol. Cell 14(7) , 2935-45, (2003) Ca2+ is an essential requirement in membrane fusion, acting through binding proteins such as calmodulin (CaM). Ca2+/CaM is required for early endosome fusion in vitro, however, the molecular basis for this requirement is unknown. An additional requirement for... |
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Occurrence of novel types of nitric oxide synthase in the silkworm, Bombyx mori.
Biochem. Biophys. Res. Commun. 207(1) , 452-9, (1995) Nitric oxide (NO) synthase activity was detected in fat body and the Malpighian tubles of the silkworm, Bombyx mori. Main NO synthase activity in the fat body was Ca(2+)/calmodulin-dependent, inducible by bacterial lipopolysaccharide (LPS) and required NADPH,... |
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Regulation of immune complexes binding of macrophages by pectic polysaccharide from Bupleurum falcatum L.: pharmacological evidence for the requirement of intracellular calcium/calmodulin on Fc receptor up-regulation by bupleuran 2IIb.
J. Pharm. Pharmacol. 47(2) , 152-6, (1995) The pectic polysaccharide, bupleuran 2IIb, up-regulates Fc-receptor (FcR) expression on peritoneal macrophages in a dose-dependent manner. The intracellular signal transduction by bupleuran 2IIb leading to the expression of FcR was studied. Neither the protei... |
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Calmodulin-antagonists inhibit vesicular Ca2+ uptake in Dictyostelium.
Cell Calcium 19(2) , 105-11, (1996) Chemotactic stimulation by cAMP elicits Ca2+ entry across the plasma membrane and uptake into intracellular Ca2+ stores. In order to better understand Ca2+ regulation in Dictyostelium we measured 45Ca2+ uptake in homogenates of aggregation competent cells. Be... |
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Arachidonic acid activates NADPH oxidase by a direct, calmodulin-regulated mechanism.
Prostaglandins Other Lipid Mediat. 56(1) , 1-6, (1998) In intact neutrophils, arachidonic acid rapidly and transiently activated NADPH oxidase-mediated superoxide generation. Inhibitors of protein kinases (staurosporine and H-7) failed to markedly attenuate arachidonic acid-stimulated superoxide generation. Conve... |
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Involvement of calmodulin and protein kinase C in cholecystokinin release by bombesin from STC-1 cells.
Pancreas 21(3) , 231-9, (2000) The mouse intestinal neuroendocrine tumor cell line STC-1 secretes cholecystokinin (CCK) and other hormones. We investigated the role of Ca2+, calmodulin (CaM), and protein kinase C (PKC) in the regulation of CCK release from STC-1 cells. Phorbol 12-myristate... |
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Evidence for calcium/calmodulin dependence of spinule retraction in retinal horizontal cells.
Vis. Neurosci. 12(3) , 413-24, (1995) Horizontal cells of the carp retina alter their synaptic connections with cones during dark and light adaptation. At light onset, dendrites of horizontal cells, which are positioned laterally at the ribbon synapse, form "spinules," little processes with membr... |
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Enhancement of the cAMP-induced apolipoprotein-mediated cellular lipid release by calmodulin inhibitors W7 and W5 from RAW 264 mouse macrophage cell line cells.
J. Cardiovasc. Pharmacol. 36(5) , 609-16, (2000) Apolipoprotein (apo) A-I generates high-density lipoprotein (HDL) by removing cellular cholesterol and phospholipid on the interaction with cells as a main source of plasma HDL. The reaction is induced by dibutylyl cyclic (dbc) adenosine monophosphate (AMP) i... |
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W-5 and quin 2-AM reverse the inhibitory effect of insulin on lipolysis due to dibutyryl cAMP.
Diabetes Res. Clin. Pract. 44(2) , 101-6, (1999) The effects of W-5, a weak calmodulin antagonist, and quin 2-AM, a cell permeant calcium chelator, on lipolysis and antilipolytic activity of insulin were studied in isolated rat adipocytes. We have previously shown that W-7, a strong calmodulin antagonist, s... |