Nω-单甲基-L-精氨酸乙酸盐
Nω-单甲基-L-精氨酸乙酸盐结构式
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常用名 | Nω-单甲基-L-精氨酸乙酸盐 | 英文名 | L-NMMA acetate |
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| CAS号 | 53308-83-1 | 分子量 | 248.279 | |
| 密度 | N/A | 沸点 | 392.7ºC at 760 mmHg | |
| 分子式 | C9H20N4O4 | 熔点 | 180-190ºC | |
| MSDS | 中文版 美版 | 闪点 | 191.3ºC |
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Evidence of oxidative stress and mitochondrial respiratory chain dysfunction in an in vitro model of sepsis-induced kidney injury.
Biochim. Biophys. Acta 1837(10) , 1790-800, (2014) To investigate the role of oxidative stress and/or mitochondrial impairment in the occurrence of acute kidney injury (AKI) during sepsis, we developed a sepsis-induced in vitro model using proximal tubular epithelial cells exposed to a bacterial endotoxin (li... |
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PRMT9 is a type II methyltransferase that methylates the splicing factor SAP145.
Nat. Commun. 6 , 6428, (2015) The human genome encodes a family of nine protein arginine methyltransferases (PRMT1-9), whose members can catalyse three distinct types of methylation on arginine residues. Here we identify two spliceosome-associated proteins-SAP145 and SAP49-as PRMT9-bindin... |
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Heparin modulation on hepatic nitric oxide synthase in experimental steatohepatitis.
Exp. Ther. Med. 8(5) , 1551-1558, (2014) Nonalcoholic fatty liver disease (NAFLD) is considered to be a hepatic manifestation of metabolic syndrome, and has been etiologically associated with insulin resistance (IR). The histopathology of NAFLD ranges between simple steatosis and nonalcoholic steato... |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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Action of anti-M₃muscarinic acetylcholine receptor IgG of primary Sjögren's syndrome on the enzymatic antioxidant system in rat submandibular gland.
J. Oral. Pathol. Med. 44 , 876-83, (2015) We demonstrate that serum immunoglobulin G (IgG) directed against glandular M3 muscarinic acetylcholine receptors (M₃mAChR) and pilocarpine triggers the increment of superoxide dismutase (SOD) and catalase (CAT) and the production of nitric oxide (NO) and pro... |
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Digital plethysmography and arginine metabolism in prehypertension: effect of nebivolol therapy.
J. Clin. Hypertens. (Greenwich.) 17(1) , 14-9, (2015) Prehypertension is an important phenotype for cardiovascular risk and development of established hypertension. To better understand the early circulatory changes in this group, the authors studied 34 patients with prehypertension (blood pressure 120-139/80-89... |
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IL-18 enhances immunosuppressive responses by promoting differentiation into monocytic myeloid-derived suppressor cells.
J. Immunol. 193(11) , 5453-60, (2014) Myeloid-derived suppressor cells (MDSCs) are major immunosuppressive cells that lead to T cell defects in cancer. IL-18 is important in inflammatory and immune responses. IL-18 has been reported to have a dual effect on tumor progression, as it not only stimu... |
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Cytokines induce protein kinase A-mediated signalling by a redox-dependent mechanism in rat renal mesangial cells.
Biochem. Pharmacol. 93(3) , 362-9, (2015) Glomerular mesangial cells are smooth muscle cell-like pericytes and are regarded as key players in kidney diseases. In an inflammatory setting, these cells produce high amounts of inflammatory cytokines, chemokines and redox mediators such as reactive oxygen... |
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In vitro anti-leishmanial efficacy of potato tuber extract (PTEx): leishmanial serine protease(s) as putative target.
Exp. Parasitol. 146 , 11-9, (2014) Leishmaniasis, a neglected tropical disease (NTD) causes major health problems in the tropical and subtropical world. Most of the antileishmanial modern therapies with different formulations of pentavalent antimonials, Miltefosine, Amphotericin B etc. are not... |
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Sarsaparilla (Smilax Glabra Rhizome) Extract Inhibits Cancer Cell Growth by S Phase Arrest, Apoptosis, and Autophagy via Redox-Dependent ERK1/2 Pathway.
Cancer Prev. Res. (Phila.) 8 , 464-74, (2015) Cancer is still the major cause of death across the world. Regular approaches cannot effectively solve the emerging problems, including drug/radiation resistance, side effects, and therapeutic ineffectiveness. Natural dietary supplements have shown effectiven... |