亚硝酸异丁酯
一般危化品
亚硝酸异丁酯结构式
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常用名 | 亚硝酸异丁酯 | 英文名 | Isobutyl nitrite |
|---|---|---|---|---|
| CAS号 | 542-56-3 | 分子量 | 103.120 | |
| 密度 | 1.0±0.1 g/cm3 | 沸点 | 70.5±9.0 °C at 760 mmHg | |
| 分子式 | C4H9NO2 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | -21.1±0.0 °C | |
| 符号 |
GHS02, GHS07, GHS08 |
信号词 | Danger |
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Vascular and hemodynamic differences between organic nitrates and nitrites.
J. Pharmacol. Exp. Ther. 280(1) , 326-31, (1997) Because nitroglycerin (NTG, an organic nitrate) and isoamyl nitrite have similar chemical structures and a common mechanism of vascular relaxation (i.e., conversion to nitric oxide in vascular tissues and activation of guanylyl cyclase), it has often been ass... |
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Vibrational analysis of n-butyl, isobutyl, sec-butyl and tert-butyl nitrite.
Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 67(1) , 178-87, (2007) Raman and infrared spectra of n-butyl, isobutyl, sec-butyl and tert-butyl nitrite are reported. Density functional theory and Møeller-Plesset calculations with 6-31G* and 6-311G* basis sets were used to determine ground state molecular geometries and vibratio... |
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Inflammatory macrophage nuclear factor-kappaB and proteasome activity are inhibited following exposure to inhaled isobutyl nitrite.
J. Leukoc. Biol. 69(4) , 639-44, (2001) A history of abuse of nitrite inhalants has been correlated with HIV seropositivity and Kaposi's sarcoma. A series of 14 daily, 45-min exposures of mice to 900-ppm isobutyl nitrite in an inhalation chamber reduced the number of peritoneal exudate macrophages ... |
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Isobutyl nitrite liberates nitric oxide which is not responsible for the immunotoxicity of the inhalant.
Adv. Exp. Med. Biol. 437 , 265-8, (1998)
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Pharmacokinetics of a model organic nitrite inhalant and its alcohol metabolite in rats.
Drug Metab. Dispos. 28(4) , 386-91, (2000) Volatile organic nitrites were originally used to relieve the chest pain that is associated with angina pectoris. Today, these inhalants are predominantly used as drugs of abuse. Little is known regarding the bioavailability and disposition of volatile nitrit... |
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Pitfalls in the toxicological analysis of an isobutyl nitrite-adulterated coffee drink.
Anal. Chem. 72(21) , 5187-92, (2000) A forensic investigation was carried out on one poisoning case, where cyanide was first detected in an evidence sample of a canned coffee drink. A more complete study revealed that it had been adulterated with isobutyl nitrite (IBN) and not cyanide. We examin... |
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Leukopenia and altered hematopoietic activity in mice exposed to the abused inhalant, isobutyl nitrite.
Exp. Hematol. 24(7) , 848-53, (1996) Isobutyl nitrite is representative of a group of inhalants abused primarily by male homosexuals; abuse of this drug may be a risk factor for AIDS or Kaposi's sarcoma. Using a 14-day exposure regimen, we previously reported that inhaled isobutyl nitrite was im... |
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Acute inhalation exposure to isobutyl nitrite causes nonspecific blood cell destruction.
Exp. Hematol. 24(5) , 592-6, (1996) Abuse of nitrite inhalants is widespread among male homosexuals and has been epidemiologically correlated with seropositivity to human immunodeficiency virus (HIV) and to Kaposi's sarcoma. These drugs may act as cofactors in AIDS if they compromise the abilit... |
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Hyperbaric oxygenation in the treatment of life-threatening isobutyl nitrite-induced methemoglobinemia--a case report.
Inhal. Toxicol. 18(13) , 1047-9, (2006) Methemoglobinemia usually results from exposure to oxidizing substances such as nitrates or nitrites. Iron within hemoglobin is oxidized from the ferrous (Fe2+) state to the ferric (Fe3+) state, resulting in the inability to transport oxygen and carbon dioxid... |
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Acute exposure to the abused inhalant, isobutyl nitrite, reduced T cell responsiveness and spleen cellularity.
Toxicol. Lett. 116(1-2) , 151-8, (2000) Isobutyl nitrite is an inhalant abused principally by male homosexuals. We have reported that subchronic inhalation exposure (45 min/day for 14 days) to 900 ppm isobutyl nitrite was immunosuppressive. In the present study, the effects of acute exposure to the... |