1,2-苯并异噻唑啉-3-酮
1,2-苯并异噻唑啉-3-酮结构式
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常用名 | 1,2-苯并异噻唑啉-3-酮 | 英文名 | Benzisothiazolone |
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| CAS号 | 2634-33-5 | 分子量 | 151.19 | |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 204.5±23.0 °C at 760 mmHg | |
| 分子式 | C7H5NOS | 熔点 | 154-158ºC | |
| MSDS | 中文版 美版 | 闪点 | 77.5±22.6 °C | |
| 符号 |
GHS05, GHS07, GHS09 |
信号词 | Danger |
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Benzisothiazolinone as a useful template for the design of new monoacylglycerol lipase inhibitors: investigation of the target residues and comparison with octhilinone.
Bioorg. Med. Chem. Lett. 21(24) , 7321-4, (2011) The regulation of 2-arachidonoylglycerol (2-AG) levels is a major issue as 2-AG has been proven to participate in numerous physiopathological phenomena such as neuroprotection or analgesia. Octhilinone, a cysteine-reagent compound, has recently been shown to ... |
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Solid-phase synthesis of benzisothiazolones as serine protease inhibitors.
Bioorg. Med. Chem. Lett. 9(5) , 663-6, (1999) An efficient solid-phase synthesis of benzisothiazolone-1,1-dioxide-based serine protease inhibitors involving alkylation of carboxylic acids with N-(bromomethyl)benzisothiazolone-1,1-dioxide has been developed. An example using this procedure for preparation... |
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A colorimetric assay for high-throughput screening of inhibitors of herpes simplex virus type 1 alkaline nuclease.
Anal. Biochem. 293(2) , 239-45, (2001) Herpes simplex virus type 1 (HSV-1) encodes a deoxyribonuclease that is frequently referred to as alkaline nuclease (AN) because of its elevated pH optimum. Studies with recombinant viruses which contain deletions in the HSV-1 gene encoding AN have indicated ... |
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ppGpp accumulation in Pseudomonas aeruginosa and Pseudomonas fluorescens subjected to nutrient limitation and biocide exposure.
Lett. Appl. Microbiol. 29(5) , 298-302, (1999) The effect of a commonly used biocide, 1,2-benzisothiazolin-3-one (BIT) on ppGpp accumulation in the pathogen, Pseudomonas aeruginosa PAO1, and an environmental isolate, Ps. fluorescens, was examined. It is concluded that BIT is able to induce a stringent res... |
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Comparison of in vitro and ex vivo antiplatelet effects of 1,2-benzisothiazolin-3-one and its 2-amino derivative.
Arzneimittelforschung 49(11) , 896-9, (1999) The in vitro and ex vivo antiplatelet effects of 2-amino-1,2-benzisothiazolin-3-one (1) are compared with those of its parent compound 1,2-benzisothiazolin-3-one (2) and with acetylsalicylic acid (ASA) against different agonists. 2-Amino-1,2-benzisothiazolin-... |
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Systemic allergic dermatitis following airborne exposure to 1,2-benzisothiazolin-3-one.
Contact Dermatitis 67(5) , 310-2, (2012)
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Allergic contact dermatitis to 1,2-benzisothiazolin-3-one in the water softener manufacturing industry.
Contact Dermatitis 61(3) , 184-5, (2009)
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Occupational contact dermatitis to 1,2-benzisothiazolin-3-one and 5-chloro-2-methylisothiazolin-3-one/2-methylisothiazolin-3-one in paint manufacturers.
Contact Dermatitis 53(2) , 115-6, (2005)
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Occupational allergic contact dermatitis caused by 1,2-benzisothiazolin-3-one in a varnish maker, followed by sensitization to benzalkonium chloride in Oilatum Plus bath additive.
Contact Dermatitis 50(2) , 104-5, (2004)
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Re: Marchetti MG, Finzi G, Cugini P, Manfrini M, Salvatorelli G. Hospital use of decontaminating mats. J Hosp Infect 2003;55:68-72.
J. Hosp. Infect. 56(2) , 166-7, (2004)
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