2-氨基嘧啶
2-氨基嘧啶结构式
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常用名 | 2-氨基嘧啶 | 英文名 | 2-Aminopyrimidine |
|---|---|---|---|---|
| CAS号 | 109-12-6 | 分子量 | 95.10 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 148.0±23.0 °C at 760 mmHg | |
| 分子式 | C4H5N3 | 熔点 | 122-126 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 43.3±22.6 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Cocrystals of 5-fluorocytosine. I. Coformers with fixed hydrogen-bonding sites.
Acta Crystallogr. B 68(Pt 4) , 431-43, (2012) The antifungal drug 5-fluorocytosine (4-amino-5-fluoro-1,2-dihydropyrimidin-2-one) was cocrystallized with five complementary compounds in order to better understand its drug-receptor interaction. The first two compounds, 2-aminopyrimidine (2-amino-1,3-diazin... |
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Synthesis and Structural Study of Some Pyrimidinium Hexafluoridosilicates.
Acta Chim. Slov. 62 , 297-303, (2015) The synthesis and spectroscopic characterization of some pyrimidinium hexafluoridosilicate salts with the formula (RH)2[SiF]6 (where R = 2-aminopyrimidine (1), cytosine (2) and 5-cyanocytosine (3)) is obtained in the reaction of SiO2 with hydrofluoric acid so... |
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Synthesis and cytotoxic activity of 2-methylimidazo[1,2-a]pyridine- and quinoline-substituted 2-aminopyrimidine derivatives.
Eur. J. Med. Chem. 45 , 379-86, (2010) A series of 2-methylimidazo[1,2-a]pyridine- and quinoline-substituted 2-aminopyrimidines derivatives were synthesized using a convenient synthetic route. We evaluate the isosteric replacement of methyl groups in 4-(2-methylimidazo[1,2-a]pyridin-3-yl)-N-p-toly... |
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Assessment of antiplatelet activity of 2-aminopyrimidines.
Eur. J. Med. Chem. 50 , 428-32, (2012) A series of 4,6-diaryl-2-aminopyrimidines was developed as antiplatelet agents and their potency was evaluated by in vitro assay. Compound 14k was found to be two times more potent than aspirin. These encouraging results could be helpful for the development o... |
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2-Aminopyrimidine as a novel scaffold for biofilm modulation.
Org. Biomol. Chem. 10(13) , 2552-61, (2012) An efficient synthetic route to a series of substituted 2-aminopyrimidine (2-AP) derivatives has been developed. Subsequent biofilm screening has allowed comparison between the biological activity of these new derivatives and that of the 2-aminoimidazole clas... |
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Spectroscopic, electronic structure and natural bond analysis of 2-aminopyrimidine and 4-aminopyrazolo[3,4-d]pyrimidine: a comparative study.
Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 96 , 226-41, (2012) The FTIR and FT-Raman spectra of 2-aminopyrimidine (2-AP) and 4-aminopyrazolo[3,4-d]pyrimidine (4-APP) has been recorded in the region 4000-400 and 3500-100 cm(-1), respectively. The tautomeric stability, optimized geometry, frequency and intensity of the vib... |
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Synthesis, molecular modeling and bio-evaluation of cycloalkyl fused 2-aminopyrimidines as antitubercular and antidiabetic agents.
Bioorg. Med. Chem. Lett. 21 , 4404-8, (2011) An economical and efficient one step synthesis of a series of 8-(arylidene)-4-(aryl)-5,6,7,8-tetrahydro-quinazolin-2-ylamines and 9-(arylidene)-4-(aryl)-6,7,8,9-tetrahydro-5H-cycloheptapyrimidin-2-ylamines by the reaction of bis-benzylidene cycloalkanones and... |
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A targeted proteomics approach to the identification of peptides modified by reactive metabolites.
Chem. Res. Toxicol. 22(5) , 853-62, (2009) Covalent binding of reactive metabolites is generally accepted as one underlying mechanism of drug-induced toxicity. However, identification of protein targets by reactive metabolites still remains a challenge due to their low abundance. Here, we report the d... |
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Discovery of a novel class of 2-aminopyrimidines as CDK1 and CDK2 inhibitors.
Bioorg. Med. Chem. Lett. 21(14) , 4203-5, (2011) A series of new 2-(2-aminopyrimidin-4-yl)phenol derivatives were synthesized as potential antitumor compounds. Substitution with pyrrolidine-3,4-diol at the 4-position of phenol provided potent inhibitory activity against CDK1 and CDK2. X-ray crystal structur... |
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Using glucaminium-based ionic liquids for improving the separation of 2-aminopyrimidine-5-ylboronic acid and its pinacol ester by high performance liquid chromatography.
J. Chromatogr. A. 1308 , 161-5, (2013) A reversed-phase high performance liquid chromatography (HPLC) method is described for the determination of boronic acids that are commonly present as impurities in pinacolboronate ester reagents. Boronic acids and their pinacolboronate esters are key reagent... |