甲基补骨脂黄酮
甲基补骨脂黄酮结构式
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常用名 | 甲基补骨脂黄酮 | 英文名 | Bavachinin |
|---|---|---|---|---|
| CAS号 | 19879-30-2 | 分子量 | 338.397 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 537.1±50.0 °C at 760 mmHg | |
| 分子式 | C21H22O4 | 熔点 | 139-145ºC | |
| MSDS | 中文版 美版 | 闪点 | 190.3±23.6 °C | |
| 符号 |
GHS09 |
信号词 | Warning |
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Phenolic compounds isolated from Psoralea corylifolia inhibit IL-6-induced STAT3 activation.
Planta Med. 78(9) , 903-6, (2012) Inhibiting interleukin-6 (IL-6) has been postulated as an effective therapy in the pathogenesis of several inflammatory diseases. In this study, seven flavonoids were isolated from the methanol extracts of Psoralea corylifolia by bioactivity-guided fractionat... |
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Antioxidative components of Psoralea corylifolia (Leguminosae).
Phytother Res. 16(6) , 539-44, (2002) A meroterpene and four flavonoids were isolated from the seeds of Psoralea corylifolia as antioxidative components. Their structures were elucidated by spectral data and identified as bakuchiol (1), bavachinin (2), bavachin (3), isobavachin (4) and isobavacha... |
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Development of a fully automated on-line solid phase extraction and high-performance liquid chromatography with diode array detection method for the pharmacokinetic evaluation of bavachinin: a study on absolute bioavailability and dose proportionality.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 893-894 , 21-8, (2012) A fully automated on-line solid-phase extraction (SPE) and high-performance liquid chromatography (HPLC) with diode array detection (DAD) method was developed for determination of bavachinin in mouse plasma. Analytical process was performed on two reversed-ph... |
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Biotransformation of bavachinin by three fungal cell cultures.
J. Biosci. Bioeng. 117(2) , 191-6, (2014) Biotransformation of bavachinin (1) was investigated using three fungal cell cultures of Aspergillus flavus ATCC 30899, Cunninghamella elegans CICC 40250 and Penicillium raistrickii ATCC 10490, respectively. Two major converted products were identified by LC/... |
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Anti-angiogenic and anti-tumor activity of Bavachinin by targeting hypoxia-inducible factor-1α.
Eur. J. Pharmacol. 691(1-3) , 28-37, (2012) Hypoxia-inducible factor-1 (HIF-1) consists of two subunits, the HIF-1β, which is constitutively expressed, and HIF-1α, which is oxygen-responsive. HIF-1α is over-expressed in response to hypoxia, increasing transcriptional activity linked to tumor progressio... |
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Prenylflavones from Psoralea corylifolia inhibit nitric oxide synthase expression through the inhibition of I-kappaB-alpha degradation in activated microglial cells.
Biol. Pharm. Bull. 28(12) , 2253-7, (2005) The overproduction of nitric oxide (NO) by inducible nitric oxide synthase (iNOS) switches the function of NO from a physiological neuromodulator to a neurotoxic effector in central nervous system (CNS) after brain injury. From the methanol extracts of Psoral... |
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Isobavachalcone and bavachinin from Psoraleae Fructus modulate Aβ42 aggregation process through different mechanisms in vitro.
FEBS Lett. 587(18) , 2930-5, (2013) Spontaneous aggregation of Aβ is a key factor in the development of Alzheimer's disease. In searching for Aβ aggregation inhibitors from traditional Chinese herbal medicines, we identified two active compounds from Psoraleae Fructus, namely isobavachalcone an... |