EMD 386088 hydrochloride
EMD 386088 hydrochloride结构式
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常用名 | EMD 386088 hydrochloride | 英文名 | EMD 386088 hydrochloride |
|---|---|---|---|---|
| CAS号 | 1171123-46-8 | 分子量 | 283.19600 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C14H16Cl2N2 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | N/A | |
| 符号 |
GHS06 |
信号词 | Danger |
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Excess of serotonin affects neocortical pyramidal neuron migration.
Transl. Psychiatry 1 , e47, (2011) The serotonin transporter (SERT) is a key molecule involved in the homeostasis of extracellular levels of serotonin and is regulated developmentally. Genetic deletion of SERT in rodents increases extracellular levels of serotonin and affects cellular processe... |
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5-HT(6) receptor agonists and antagonists enhance learning and memory in a conditioned emotion response paradigm by modulation of cholinergic and glutamatergic mechanisms.
Br. J. Pharmacol. 167(2) , 436-49, (2012) 5-HT(6) receptors are abundant in the hippocampus, nucleus accumbens and striatum, supporting their role in learning and memory. Selective 5-HT(6) receptor antagonists produce pro-cognitive effects in several learning and memory paradigms while 5-HT(6) recept... |
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The 5-HT6 receptor agonist EMD 386088 produces antidepressant and anxiolytic effects in rats after intrahippocampal administration.
Psychopharmacology 217(3) , 411-8, (2011) Preclinical data suggest a possible role for 5-HT6 receptors in depression and anxiety. However, the results of pharmacological studies are equivocal since both blockade and stimulation of 5-HT6 receptors may evoke antidepressant- and anxiolytic-like effects.... |