溴甲纳曲酮
溴甲纳曲酮结构式
|
常用名 | 溴甲纳曲酮 | 英文名 | Methylnaltrexone (Bromide) |
|---|---|---|---|---|
| CAS号 | 73232-52-7 | 分子量 | 436.33900 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C21H26BrNO4 | 熔点 | 237-239ºC | |
| MSDS | 中文版 美版 | 闪点 | N/A | |
| 符号 |
GHS06, GHS09 |
信号词 | Danger |
|
Efficacy of pharmacological therapies for the treatment of opioid-induced constipation: systematic review and meta-analysis.
Am. J. Gastroenterol. 108(10) , 1566-74; quiz 1575, (2013) There has been no definitive synthesis of the evidence for any benefit of available pharmacological therapies in opioid-induced constipation (OIC). We conducted a systematic review and meta-analysis to address this deficit.We searched MEDLINE, EMBASE, EMBASE ... |
|
|
[Opiate induced constipation--mechanisms, relevance and treatment].
Dtsch. Med. Wochenschr. 138(43) , 2207-11, (2013)
|
|
|
Effects of remifentanil on the esophagogastric junction and swallowing.
Acta Anaesthesiol. Scand. 57(8) , 1002-9, (2013) A recent study demonstrated that reflux is associated with impaired pressure augmentation in the esophagogastric junction (EGJ), caused by diaphragmal contractions during inspiration. It is unknown whether this augmentation is influenced by opioids. Swallowin... |
|
|
Methylnaltrexone for opioid-induced constipation in pediatric oncology patients.
Pediatr. Blood Cancer 60(10) , 1667-70, (2013) Pediatric oncology patients can experience opioid-induced constipation, which may not respond to laxative treatment. Methylnaltrexone is an opioid receptor antagonist that can reverse opioid-induced constipation without affecting analgesia. Published literatu... |
|
|
Giving laxatives safely and effectively.
Medsurg Nurs. 22(5) , 290-6, 302, (2013)
|
|
|
The role of methylnaltrexone in opioid-induced constipation.
S. D. Med. 66(10) , 425, 427, (2013)
|
|
|
[Constipation management in palliative care].
Krankenpfl. Soins Infirm. 106(6) , 32-3, (2013)
|
|
|
Peripheral opioid antagonist enhances the effect of anti-tumor drug by blocking a cell growth-suppressive pathway in vivo.
PLoS ONE 10(4) , e0123407, (2015) The dormancy of tumor cells is a major problem in chemotherapy, since it limits the therapeutic efficacy of anti-tumor drugs that only target dividing cells. One potential way to overcome chemo-resistance is to "wake up" these dormant cells. Here we show that... |
|
|
An unusual case of Ogilvie syndrome in a pediatric oncology patient receiving palliative care after failed treatment with neostigmine.
J. Palliat. Med. 15(9) , 1042-6, (2012) We present a case of severe refractory constipation in an adolescent oncology patient with widely metastatic clear cell osteosarcoma who was ultimately found to have Ogilvie syndrome, also known as acute colonic pseudo-obstruction (ACPO). Ogilvie syndrome is ... |
|
|
Characterization of abdominal pain during methylnaltrexone treatment of opioid-induced constipation in advanced illness: a post hoc analysis of two clinical trials.
J. Pain Symptom Manage. 42(5) , 754-60, (2011) Methylnaltrexone is a selective peripherally acting mu-opioid receptor antagonist that decreases the constipating effects of opioids without affecting centrally mediated analgesia. In two double-blind, placebo-controlled, Phase III studies of methylnaltrexone... |