Zinterol hydrochloride
Zinterol hydrochloride结构式
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常用名 | Zinterol hydrochloride | 英文名 | Zinterol hydrochloride |
|---|---|---|---|---|
| CAS号 | 38241-28-0 | 分子量 | 414.94700 | |
| 密度 | N/A | 沸点 | 574.3ºC at 760 mmHg | |
| 分子式 | C19H27ClN2O4S | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | 301.1ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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The beta3-adrenoceptor agonist 4-[[(Hexylamino)carbonyl]amino]-N-[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]-phenyl]-benzenesulfonamide (L755507) and antagonist (S)-N-[4-[2-[[3-[3-(acetamidomethyl)phenoxy]-2-hydroxypropyl]amino]-ethyl]phenyl]benzenesulfonamide (L748337) activate different signaling pathways in Chinese hamster ovary-K1 cells stably expressing the human beta3-adrenoceptor.
Mol. Pharmacol. 74(5) , 1417-28, (2008) This study identifies signaling pathways activated by the beta(2)-/beta(3)-adrenoceptor (AR) agonist zinterol, the selective beta(3)-AR agonist L755507, and the selective beta(3)-AR antagonist L748337 in CHO-K1 cells expressing human beta(3)-adrenoceptors. Zi... |
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Multiple signalling pathways involved in beta2-adrenoceptor-mediated glucose uptake in rat skeletal muscle cells.
Br. J. Pharmacol. 147(4) , 446-54, (2006) 1. Beta-adrenoceptor (AR) agonists increase 2-deoxy-[3H]-D-glucose uptake (GU) via beta2-AR in rat L6 cells. The beta-AR agonists, zinterol (beta2-AR) and (-)-isoprenaline, increased cAMP accumulation in a concentration-dependent manner (pEC50=9.1+/-0.02 and ... |
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Rapid turnover of glycogen in memory formation.
Neurochem. Res. 37(11) , 2456-63, (2012) The influence of noradrenaline acting at α(2)-AR and β(2)-ARs on the turnover of glycogen after learning has been investigated. The role of glycogen turnover in memory formation was examined using weakly-reinforced, single trial bead discrimination training i... |
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Beta(2)-adrenergic receptor agonists increase intracellular free Ca(2+) concentration cycling in ventricular cardiomyocytes through p38 and p42/44 MAPK-mediated cytosolic phospholipase A(2) activation.
J. Biol. Chem. 276(43) , 39539-48, (2001) We have recently reported that arachidonic acid mediates beta(2)-adrenergic receptor (AR) stimulation of [Ca(2+)](i) cycling and cell contraction in embryonic chick ventricular cardiomyocytes (Pavoine, C., Magne, S., Sauvadet, A., and Pecker, F. (1999) J. Bio... |
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beta(1) and beta(2)-adrenergic receptor subtype effects in German shepherd dogs with inherited lethal ventricular arrhythmias.
Cardiovasc. Res. 48(2) , 211-9, (2000) Delayed afterdepolarization-induced triggered activity originating in ventricular myocardium is a mechanism for some age-dependent, inherited ventricular tachycardias in a colony of German shepherd dogs.We used standard microelectrode techniques to study beta... |
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New insights into beta2-adrenoceptor signaling in the adult rat heart.
Cardiovasc. Res. 57(3) , 694-703, (2003) The role of cAMP in beta(2)-adrenoceptor signaling and its functional relevance in adult rat heart has been the subject of considerable controversy. Therefore, we investigated the beta(2)-adrenoceptor pathways in both adult cardiomyocytes and in the intact he... |
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beta(1)-Receptors increase cAMP and induce abnormal Ca(i) cycling in the German shepherd sudden death model.
Am. J. Physiol. Heart Circ. Physiol. 282(4) , H1181-8, (2002) We studied the role of beta-adrenergic receptor subtype signaling to cAMP and calcium in the genesis of catecholamine-dependent arrhythmias in German shepherd dogs that develop lethal arrhythmias at ~5 mo of age. There were three major findings in this study:... |
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The cytosolic phospholipase A2 pathway, a safeguard of beta2-adrenergic cardiac effects in rat.
J. Biol. Chem. 280(19) , 18881-90, (2005) We have recently demonstrated that in human heart, beta2-adrenergic receptors (beta2-ARs) are biochemically coupled not only to the classical adenylyl cyclase (AC) pathway but also to the cytosolic phospholipase A2 (cPLA2) pathway (Pavoine, C., Behforouz, N.,... |
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Release of norepinephrine from human ovary: coupling to steroidogenic response.
Endocrine 15(2) , 187-92, (2001) We investigated the possibility that norepinephrine from the human ovary is released after nerve stimulation and that this neurotransmitter is coupled to a steroidogenic response. Biologically significant levels of both norepinephrine and dopamine were found ... |
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Temporal dynamics of inotropic, chronotropic, and metabolic responses during beta1- and beta2-AR stimulation in the isolated, perfused rat heart.
Am. J. Physiol. Endocrinol. Metab. 289(3) , E412-8, (2005) During the beta-adrenergic receptor (beta-AR)-mediated stress response in the heart, the relations between functional responses and metabolism are ill defined, with the distinction between beta1- and beta2-AR subtypes creating further complexity. Specific out... |