羟基香豆素
羟基香豆素结构式
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常用名 | 羟基香豆素 | 英文名 | (+/-)-4-Hydroxy Mephenytoin |
|---|---|---|---|---|
| CAS号 | 61837-65-8 | 分子量 | 234.251 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | N/A | |
| 分子式 | C12H14N2O3 | 熔点 | 153-154ºC | |
| MSDS | 中文版 美版 | 闪点 | 9 °C | |
| 符号 |
GHS02, GHS06, GHS08 |
信号词 | Danger |
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The liver-selective NO donor, V-PYRRO/NO, protects against liver steatosis and improves postprandial glucose tolerance in mice fed high fat diet.
Biochem. Pharmacol. 93(3) , 389-400, (2015) There is an unmet medical need for novel NAFLD treatments. Here we have examined the effects of liver-selective NO donor (V-PYRRO/NO) as compared with metformin on hepatic steatosis and glucose tolerance in mice fed high fat diet.Effects of V-PYRRO/NO (5 mgkg... |
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Size- and time-dependent alteration in metabolic activities of human hepatic cytochrome P450 isozymes by gold nanoparticles via microsomal coincubations.
Nanoscale Res. Lett. 9(1) , 642, (2014) Nano-sized particles are known to interfere with drug-metabolizing cytochrome P450 (CYP) enzymes, which can be anticipated to be a potential source of unintended adverse reactions, but the mechanisms underlying the inhibition are still not well understood. He... |
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Quantification of mephenytoin and its metabolites 4'-hydroxymephenytoin and nirvanol in human urine using a simple sample processing method.
Rapid Commun. Mass Spectrom. 18(15) , 1675-80, (2004) A reliable and easy to use liquid chromatography/tandem mass spectrometry (LC/MS/MS) method without the use of sample extraction was developed for the simultaneous quantification of urinary concentrations of mephenytoin, a standard phenotyping substrate for t... |
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Enantiospecific separation and quantitation of mephenytoin and its metabolites nirvanol and 4'-hydroxymephenytoin in human plasma and urine by liquid chromatography/tandem mass spectrometry.
Rapid Commun. Mass Spectrom. 20(3) , 463-72, (2006) A sensitive method using enantiospecific liquid chromatography/tandem mass spectrometry detection for the quantitation of S- and R-mephenytoin as well as its metabolites S- and R-nirvanol and S- and R-4'-hydroxymephenytoin in plasma and urine has been develop... |
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Simultaneous enantiospecific separation and quantitation of mephenytoin and its metabolites nirvanol and 4'-hydroxymephenytoin in human plasma by liquid chromatography.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 791(1-2) , 179-91, (2003) A high-performance liquid chromatographic method for the enantiospecific quantitation of S- and R-mephenytoin and its metabolites S- and R-nirvanol and S- and R-4'-hydroxymephenytoin in plasma is described. The compounds were separated using a reversed-phase ... |
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Inhibitory mechanisms of celastrol on human liver cytochrome P450 1A2, 2C19, 2D6, 2E1 and 3A4.
Xenobiotica 45 , 571-7, (2015) 1. The present study was conducted to examine the possibility of herb-drug interaction by celastrol, which is a main compound isolated from Tripterygium wilfordii Hook F. using human liver microsomes with cocktail methods. Focused on its inhibitory manner on ... |
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Chemical inhibitors of CYP450 enzymes in liver microsomes: combining selectivity and unbound fractions to guide selection of appropriate concentration in phenotyping assays.
Xenobiotica 45(2) , 95-106, (2014) 1. Chemical inhibition is the widely used method in reaction phenotyping assays for estimation of specific enzyme contribution to a given metabolic pathway. The results from phenotyping assays depend on the selectivity of chemical inhibitor and the concentrat... |
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Inhibitory effects of calf thymus DNA on metabolism activity of CYP450 enzyme in human liver microsomes.
Drug Metab. Pharmacokinet. 29(6) , 475-81, (2015) The present study investigated the effect of calf thymus DNA (ctDNA) on human hepatic cytochrome P450s (CYP450s) in vitro. Specific substrate probes for each isoform, CYP1A2, 2C9, 2C19, 2D6 and 3A4, were incubated using pooled human liver microsomes with or w... |
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Multifaceted interaction of the traditional Chinese medicinal herb Schisandra chinensis with cytochrome P450-mediated drug metabolism in rats.
J. Ethnopharmacol. 155(3) , 1473-82, (2014) Schisandra chinensis (SC), officially listed as a sedative and tonic in the Chinese Pharmacopoeia, has been used as a common component in various prescriptions in Traditional Chinese Medicine (TCM) and more recently in western medicine for its antihepatotoxic... |
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A rapid electron-capture gas chromatographic procedure for the analysis of p-hydroxymephenytoin.
J. Pharmacol. Toxicol. Methods 44(3) , 461-5, (2000) An electron-capture gas chromatographic procedure was developed for detection and quantification of p-hydroxymephenytoin (OHMEP), a metabolite of S-mephenytoin, in human liver microsomal preparations. OHMEP was derivatized with pentafluorobenzoyl chloride (PF... |