盐酸帕吉林
盐酸帕吉林结构式
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常用名 | 盐酸帕吉林 | 英文名 | pargyline hydrochloride |
|---|---|---|---|---|
| CAS号 | 306-07-0 | 分子量 | 195.689 | |
| 密度 | N/A | 沸点 | 228.4ºC at 760 mmHg | |
| 分子式 | C11H14ClN | 熔点 | 160-163ºC | |
| MSDS | 中文版 美版 | 闪点 | 83.9ºC | |
| 符号 |
GHS06 |
信号词 | Danger |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Nat. Chem. Biol. 5 , 765-71, (2009) Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened seven parasite lines for differences in responses to 1,279... |
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Azure B and a synthetic structural analogue of methylene blue, ethylthioninium chloride, present with antidepressant-like properties.
Life Sci. 117(2) , 56-66, (2015) The phenothiazinium compound, methylene blue (MB), possesses diverse pharmacological actions and is attracting attention for the treatment of bipolar disorder and Alzheimer's disease. MB acts on both monoamine oxidase (MAO) and the nitric oxide (NO)-cGMP path... |
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Origins of stereoselectivities in chiral phosphoric acid catalyzed allylborations and propargylations of aldehydes.
J. Org. Chem. 78(3) , 1208-15, (2013) The chiral BINOL-phosphoric acid catalyzed allylboration and propargylation reactions are studied with density functional theory (B3LYP and B3LYP-D3). Two different models were recently proposed for these reactions by Goodman and our group, respectively. In G... |
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Divergent reaction pathways of homologous and isosteric propargyl amides in sequential Ru/Pd-catalyzed annulations for the synthesis of heterocycles.
J. Org. Chem. 78(8) , 3832-46, (2013) Cu-catalyzed three-component coupling of imines with benzoyl chloride and terminal arylalkynes followed by enyne ring-closing metathesis (RCM) and Heck cyclization afforded medicinally relevant benzoindolines, cyclopropane-fused indenopyridines, pyrroloquinol... |
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The metabolism of histamine in rat hypothalamus and cortex after reserpine treatment.
Neurochem. Int. 85-86 , 31-9, (2015) The effect of reserpine on histamine (HA) and tele-methylhistamine (N(τ)-MHA) in hypothalamus and cortex of rats was analyzed and compared to catecholamines. IP injection of reserpine (5 mg/kg) confirmed the effectiveness of reserpine treatment on noradrenali... |
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Cyclization of homopropargyl chalcogenides by copper(II) salts: selective synthesis of 2,3-dihydroselenophenes, 3-arylselenophenes, and 3-haloselenophenes/thiophenes.
Chemistry 19(39) , 13059-64, (2013) Copper(II) halide mediated cyclization of homopropargyl chalcogenides gave three types of chalcogenophene derivatives. Selective product formation was achieved by controlling solvent, temperature, and atmosphere. By using CuBr2 and 1,2-dichloroethane at room ... |
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Zinc catalyzed and mediated asymmetric propargylation of trifluoromethyl ketones with a propargyl boronate.
J. Org. Chem. 78(8) , 3592-615, (2013) The development of zinc-mediated and -catalyzed asymmetric propargylations of trifluoromethyl ketones with a propargyl borolane and the N-isopropyl-l-proline ligand is presented. The methodology provided moderate to high stereoselectivity and was successfully... |
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Inhibition of semicarbazide-sensitive amine oxidase attenuates myocardial ischemia-reperfusion injury in an in vivo rat model.
Leuk. Res. 88 , 302-6, (2011) This study tested the hypothesis that the inhibition of semicarbazide-sensitive amine oxidase (SSAO) after ischemia could attenuate myocardial ischemia-reperfusion (I/R) injury.Anesthetized male Sprague-Dawley rats underwent myocardial I/R injury. Saline, sem... |
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Stereoselective intermolecular C-H amination reactions.
Chem. Commun. (Camb.) 48(63) , 7799-801, (2012) A novel chiral N-mesyloxycarbamate to perform rhodium-catalyzed stereoselective C-H amination reactions is reported. Chiral benzylic and propargylic amines are produced in good yields and selectivities using ethyl acetate as solvent. The corresponding free am... |