4-甲氧基苯酚(MEHQ)
4-甲氧基苯酚(MEHQ)结构式
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常用名 | 4-甲氧基苯酚(MEHQ) | 英文名 | Mequinol |
|---|---|---|---|---|
| CAS号 | 150-76-5 | 分子量 | 124.137 | |
| 密度 | 1.1±0.1 g/cm3 | 沸点 | 243.0±0.0 °C at 760 mmHg | |
| 分子式 | C7H8O2 | 熔点 | 56 °C | |
| MSDS | 中文版 美版 | 闪点 | 120.8±4.8 °C | |
| 符号 |
GHS07, GHS08 |
信号词 | Warning |
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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Chem. Res. Toxicol. 23 , 171-83, (2010) Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental drug discovery projects toward safer medicines. In this st... |
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Convenient QSAR model for predicting the complexation of structurally diverse compounds with β-cyclodextrins
Bioorg. Med. Chem. 17 , 896-904, (2009) This paper reports a QSAR study for predicting the complexation of a large and heterogeneous variety of substances (233 organic compounds) with beta-cyclodextrins (beta-CDs). Several different theoretical molecular descriptors, calculated solely from the mole... |
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Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
J. Med. Chem. 48 , 3269-79, (2005) Growing interest in the use of both the logarithm of the partition coefficient of the neutral species in the alkane/water system (log P(N)(alk)) and the difference between log P(N)(oct) (the logarithm of the partition coefficient of the neutral species in the... |
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Cellular apoptosis and cytotoxicity of phenolic compounds: a quantitative structure-activity relationship study.
J. Med. Chem. 48 , 7234-42, (2005) In this comprehensive study on the caspase-mediated apoptosis-inducing effect of 51 substituted phenols in a murine leukemia cell line (L1210), we determined the concentrations needed to induce caspase activity by 50% (I50) and utilized these data to develop ... |
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Improved thin-layer chromatography bioautographic assay for the detection of actylcholinesterase inhibitors in plants.
Phytochem. Anal. 22(6) , 509-15, (2011) Thin-layer chromatography (TLC) bioautographic method is a simple and rapid method to screen acetylcholinesterase inhibitors from plant extracts. However, the high consumption of enzyme (6 U/mL) in current methods makes the procedure expensive, which is an ob... |
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Molecularly imprinted polymers for cleanup and selective extraction of curcuminoids in medicinal herbal extracts.
Anal. Bioanal. Chem 407(3) , 803-12, (2015) This paper describes the synthesis of novel molecularly imprinted polymers (MIPs), prepared by a noncovalent imprinting approach, for cleanup and preconcentration of curcumin (CUR) and bisdemethoxycurcumin (BDMC) from medicinal herbal extracts and further ana... |
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Nonclinical evaluation of novel cationically modified polysaccharide antidotes for unfractionated heparin.
PLoS ONE 10(3) , e0119486, (2015) Protamine, the only registered antidote of unfractionated heparin (UFH), may produce a number of adverse effects, such as anaphylactic shock or serious hypotension. We aimed to develop an alternative UFH antidote as efficient as protamine, but safer and easie... |
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Spatial control of cell gene expression by siRNA gradients in biodegradable hydrogels.
Adv. Healthc. Mater. 4(5) , 714-22, (2015) The extracellular environment exposes cells to numerous biochemical and physical signals that regulate their behavior. Strategies for generating continuous gradients of signals in biomaterials may allow for spatial control and patterning of cell behavior, and... |
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Acute alcohol intoxication-induced microvascular leakage.
Alcohol. Clin. Exp. Res. 38(9) , 2414-26, (2014) Alcohol intoxication can increase inflammation and worsen injury, yet the mechanisms involved are not clear. We investigated whether acute alcohol intoxication increases microvascular permeability and investigated potential signaling mechanisms in endothelial... |
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Downregulation of Gabra4 expression during alcohol withdrawal is mediated by specific microRNAs in cultured mouse cortical neurons.
Brain Behav. 5 , e00355, (2015) Alcohol abuse and dependence are a serious public health problem. A large number of alcohol-regulated genes, (ARGs) are known to be influenced by alcohol use and withdrawal (AW), and recent evidence suggests that neuroadaptation to alcohol may be due in part ... |