非诺班
非诺班结构式
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常用名 | 非诺班 | 英文名 | Fenobam |
|---|---|---|---|---|
| CAS号 | 57653-26-6 | 分子量 | 266.68400 | |
| 密度 | 1.47 g/cm3 | 沸点 | N/A | |
| 分子式 | C11H11ClN4O2 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | N/A | |
| 符号 |
GHS06 |
信号词 | Danger |
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Pharmacophoric features of drugs with guanylurea moiety: an electronic structure analysis.
J. Mol. Model. 19(4) , 1865-74, (2013) Several therapeutically important compounds contain guanylurea (GU) moiety. The appropriate tautomeric state of these species has not been explored, preliminary studies indicated that the traditional representation of this class of compounds use a high energy... |
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Inhibition of Group I Metabotropic Glutamate Receptors Reverses Autistic-Like Phenotypes Caused by Deficiency of the Translation Repressor eIF4E Binding Protein 2.
J. Neurosci. 35 , 11125-32, (2015) Exacerbated mRNA translation during brain development has been linked to autism spectrum disorders (ASDs). Deletion of the eukaryotic initiation factor 4E (eIF4E)-binding protein 2 gene (Eif4ebp2), encoding the suppressor of mRNA translation initiation 4E-BP2... |
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Insights into the interaction of negative allosteric modulators with the metabotropic glutamate receptor 5: discovery and computational modeling of a new series of ligands with nanomolar affinity.
Bioorg. Med. Chem. 23 , 3040-58, (2015) Metabotropic glutamate receptor 5 (mGlu5) is a biological target implicated in major neurological and psychiatric disorders. In the present study, we have investigated structural determinants of the interaction of negative allosteric modulators (NAMs) with th... |
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mGluR5 antagonist-induced psychoactive properties: MTEP drug discrimination, a pharmacologically selective non-NMDA effect with apparent lack of reinforcing properties.
J. Pharmacol. Exp. Ther. 349(1) , 155-64, (2014) Fenobam [N-(3-chlorophenyl)-N'-(4,5-dihydro-1-methyl-4-oxo-1H-imidazole-2-yl)urea], a potent metabotropic glutamate mGluR5 receptor antagonist, reported to have analgesic effects in animals and anxiolytic effects in humans, also caused adverse events, includi... |
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A-kinase anchoring protein 79/150 coordinates metabotropic glutamate receptor sensitization of peripheral sensory neurons.
Pain 156 , 2364-72, (2015) Glutamate serves as the primary excitatory neurotransmitter in the nervous system. Previous studies have identified a role for glutamate and group I metabotropic receptors as targets for study in peripheral inflammatory pain. However, the coordination of sign... |
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Differential regulation of mGlu5 R and ΜOPr by priming- and cue-induced reinstatement of cocaine-seeking behaviour in mice.
Addict. Biol. 20 , 902-12, (2015) The key problem for the treatment of drug addiction is relapse to drug use after abstinence that can be triggered by drug-associated cues, re-exposure to the drug itself and stress. Understanding the neurobiological mechanisms underlying relapse is essential ... |
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Metabotropic glutamate receptor 5 antagonism with fenobam: examination of analgesic tolerance and side effect profile in mice.
Anesthesiology 115(6) , 1239-50, (2011) The metabotropic glutamate receptor 5 noncompetitive antagonist fenobam is analgesic in rodents. Future development of fenobam as an analgesic in humans will require a favorable long-term treatment profile and a lack of significant deleterious side effects. T... |
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Polymorphism and tautomeric preference in fenobam and the utility of NLO response to detect polymorphic impurities.
Chem. Commun. (Camb.) 48(85) , 10559-61, (2012) Crystal structures of polymorphs and solvatomorphs of the potential anxiolytic drug fenobam exhibit an exclusive preference for one of the two possible tautomeric structures. A novel methodology based on nonlinear optical response has been successfully employ... |
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In vitro and in vivo metabolism of the antianxiolytic agent fenobam in the rat.
J. Pharm. Sci. 84(2) , 185-9, (1995) Fenobam [(Fn); N-(3-chlorophenyl)-N-(4,5-dihydro-1-methyl-4-oxo-1H-imidazole-2-yl)urea] sulfate is a novel agent with potent anxiolytic activity in rats. [14C]Fn sulfate was administered as an oral solution (250 mg/kg) to male Wistar rats, and 52% of the admi... |
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1H- and 13C-NMR spectra of fenobam.
J. Pharm. Sci. 72(2) , 189-90, (1983)
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