β-拉帕醌
β-拉帕醌结构式
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常用名 | β-拉帕醌 | 英文名 | Beta-Lapachone |
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| CAS号 | 4707-32-8 | 分子量 | 242.270 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 381.4±42.0 °C at 760 mmHg | |
| 分子式 | C15H14O3 | 熔点 | >110ºC (dec.) | |
| MSDS | 美版 | 闪点 | 169.7±27.9 °C |
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Light effect on the stability of β-lapachone in solution: pathways and kinetics of degradation.
J. Pharm. Pharmacol. 63(9) , 1156-60, (2011) The purpose of this work was to study the chemical stability of the new antitumoral β-lapachone (βLAP) to determine the degradation pathway/s of the molecule and the degradation kinetics in addition to identifying several degradation products.Samples of βLAP ... |
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Temperature-sensitive gels for intratumoral delivery of β-lapachone: effect of cyclodextrins and ethanol.
ScientificWorldJournal 2012 , 126723, (2012) This work evaluated the potential of Pluronics (varieties F127 and P123) in combination with solubilizing agents to be used as syringeable in situ gelling depots of intratumoral β-lapachone (βLAP). Pluronic dispersions prepared at various concentrations in th... |
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Ultrastructural analysis of β-lapachone-induced surface membrane damage in male adult Schistosoma mansoni BH strain worms.
Exp. Parasitol. 142 , 83-90, (2014) The present study provides, for the first time, conclusions on the in vitro schistosomicidal properties of β-lap. Adult male Schistosoma mansoni worms of the BH strain were used for the study. Motility, mortality, cell viability and alterations in the tegumen... |
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Mechanistic studies of cancer cell mitochondria- and NQO1-mediated redox activation of beta-lapachone, a potentially novel anticancer agent.
Toxicol. Appl. Pharmacol. 281(3) , 285-93, (2014) Beta-lapachone (beta-Lp) derived from the Lapacho tree is a potentially novel anticancer agent currently under clinical trials. Previous studies suggested that redox activation of beta-Lp catalyzed byquinone oxidoreductase 1 (NQO1) accounted for its killing o... |
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β-Lapachone analogs with enhanced antiproliferative activity
Eur. J. Med. Chem. 53 , 264-74, (2012) In this study, we describe the synthesis of a series of α- and β-lapachone containing hydroxyl or methoxyl groups on the benzene ring, by means of the selective acid promoted cyclization of the appropriate lapachol analog. The evaluation of the antiproliferat... |
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β-lapachone accelerates the recovery of burn-wound skin.
Histol. Histopathol. 26(7) , 905-14, (2011) β-lapachone is a quinone of lapachol extracted from the bark of lapacho tree. Recent findings demonstrated that punched skin wounds of mice healed faster with β-lapachone treatment. The present study investigates the effects of β-lapachone on burn-wound skin ... |
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β-Lapachone induces heart morphogenetic and functional defects by promoting the death of erythrocytes and the endocardium in zebrafish embryos.
J. Biomed. Sci. 18 , 70, (2011) β-Lapachone has antitumor and wound healing-promoting activities. To address the potential influences of various chemicals on heart development of zebrafish embryos, we previously treated zebrafish embryos with chemicals from a Sigma LOPAC1280™ library and fo... |
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Screening of anti-cancer agent using zebrafish: comparison with the MTT assay.
Biochem. Biophys. Res. Commun. 422(1) , 85-90, (2012) The MTT (3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyltetrazolium bromide) assay is a classical method for screening cytotoxic anti-cancer agents. Candidate drugs from the MTT assay need in vivo models to test their efficiency and to assess the absorption, distri... |
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Smart design of intratumoral thermosensitive β-lapachone hydrogels by Artificial Neural Networks
Int. J. Pharm. 433(1-2) , 112-8, (2012) This study presents Artificial Neural Networks (ANN) as a tool for designing injectable intratumoral formulations of the anticancer drug β-lapachone. This methodology permits insight into the interactions between variables and determines the design space of t... |
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The encapsulation of β-lapachone in 2-hydroxypropyl-β-cyclodextrin inclusion complex into liposomes: a physicochemical evaluation and molecular modeling approach.
Eur. J. Pharm. Sci. 44(3) , 332-40, (2011) The aim of this study was to encapsulate lapachone (β-lap) or inclusion complex (β-lap:HPβ-CD) in liposomes and to evaluate their physicochemical characteristics. In addition, the investigation of the main aspects of the interaction between β-lap and 2-hydrox... |