硫酸卡那霉素
硫酸卡那霉素结构式
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常用名 | 硫酸卡那霉素 | 英文名 | kanamycin acid sulfate |
|---|---|---|---|---|
| CAS号 | 64013-70-3 | 分子量 | 680.65600 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C18H40N4O19S2 | 熔点 | >260℃ | |
| MSDS | 美版 | 闪点 | N/A | |
| 符号 |
GHS08 |
信号词 | Danger |
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Loss of Slc4a1b chloride/bicarbonate exchanger function protects mechanosensory hair cells from aminoglycoside damage in the zebrafish mutant persephone.
PLoS Genet. 8(10) , e1002971, (2012) Mechanosensory hair cell death is a leading cause of hearing and balance disorders in the human population. Hair cells are remarkably sensitive to environmental insults such as excessive noise and exposure to some otherwise therapeutic drugs. However, individ... |
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Aminoglycosides inhibit KCNQ4 channels in cochlear outer hair cells via depletion of phosphatidylinositol(4,5)bisphosphate.
Mol. Pharmacol. 79 , 51-60, (2011) Aminoglycoside antibiotics (AGs) are severely ototoxic. AGs cause degeneration of outer hair cells (OHCs), leading to profound and irreversible hearing loss. The underlying mechanisms are not fully understood. OHC survival critically depends on a specific K+ ... |
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Delayed commitment to evolutionary fate in antibiotic resistance fitness landscapes.
Nat. Commun. 6 , 7385, (2015) Predicting evolutionary paths to antibiotic resistance is key for understanding and controlling drug resistance. When considering a single final resistant genotype, epistatic contingencies among mutations restrict evolution to a small number of adaptive paths... |