螺内酯

螺内酯结构式
螺内酯
常用名 螺内酯 英文名 Spironolactone
CAS号 52-01-7 分子量 416.573
密度 1.2±0.1 g/cm3 沸点 597.0±50.0 °C at 760 mmHg
分子式 C24H32O4S 熔点 207-208 °C(lit.)
MSDS螺内酯的MSDS|SDS|pdf下载 中文版 美版 闪点 302.3±18.1 °C
符号 GHS08
GHS08
信号词 Danger

Evidence for aldosterone-dependent growth of renal cell carcinoma.

Int. J. Exp. Pathol. 95(4) , 244-50, (2014)

The aim if this study was to investigate the hypothesis that K-RAS 4A is upregulated in a mineralocorticoid-dependent manner in renal cell carcinoma and that this supports the proliferation and survival of some renal cancers. Expression of the K-RAS in renal ...

Mineralocorticoid receptor blockade improves coronary microvascular function in individuals with type 2 diabetes.

Diabetes 64(1) , 236-42, (2015)

Reduced coronary flow reserve (CFR), an indicator of coronary microvascular dysfunction, is seen in type 2 diabetes mellitus (T2DM) and predicts cardiac mortality. Since aldosterone plays a key role in vascular injury, the aim of this study was to determine w...

Patient with purulent pericarditis: a case doomed to fail?

Kardiol. Pol. 71(2) , 176-8, (2013)

Exudative pericarditis, and in particular a purulent type, is a rare condition which requires emergency medical intervention. In our paper we present a case report concerning a patient with purulent pericarditis.

A chrysin analog exhibited strong inhibitory activities against both PGE2 and NO production.

Am. J. Physiol. Regul. Integr. Comp. Physiol. 305(10) , R1133-40, (2013)

A number of 8-substituted chrysin analogs have been prepared and evaluated for their inhibitory activities of cyclooxygenase-2 catalyzed prostaglandin E(2) and iNOS-mediated NO production. Analogs were prepared via Suzuki-Miyaura C-C cross coupling reaction o...

Mineralocorticoid receptor agonists induce mouse aortic aneurysm formation and rupture in the presence of high salt.

Arterioscler. Thromb. Vasc. Biol. 33(7) , 1568-79, (2013)

Elevated plasma aldosterone concentrations in patients have been linked to a spectrum of cardiovascular diseases. Mineralocorticoid receptor antagonists provide additional benefits in patients with heart failure. However, whether aldosterone and the mineraloc...

83-year-old man with abdominal swelling and lower extremity edema.

Mayo Clin. Proc. 88(10) , e115-8, (2013)

[Influence of non-sodium restricted diet with diuretics on plasma rennin, renal blood flow and in patients with cirrhotic ascites].

Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 27(1) , 50-3, (2013)

To explore influence of sodium restricted diet and non-sodium restricted diet on plasma rennin (PRA), angiotensin II (All), ALD, renal blood flow (RBF) and subside of ascites in patients with cirrhotic ascites.Eighty cases of hepatitis B with cirrhotic ascite...

Neonatal diuretic therapy: furosemide, thiazides, and spironolactone.

Clin. Perinatol. 39(1) , 209-20, (2012)

Diuretics are commonly used to treat infants with oxygen-dependent chronic lung disease. However, there are limited data suggesting a beneficial effect of long-term diuretic therapy on pulmonary function or clinical outcome in this population. Furthermore, da...

Predisposing factors for acute kidney injury in Hispanic patients treated with diuretics for decompensated heart failure.

P. R. Health Sci. J. 32(2) , 63-7, (2013)

In patients with congestive heart failure (CHF), use of loop diuretic therapy may result in acute kidney insufficiency (AKI). We assessed the factors that contributed to the development of AKI in patients with CHF treated with loop diuretics in a sample of pa...

Spironolactone decreases the somatic signs of opiate withdrawal by blocking the mineralocorticoid receptors (MR).

Toxicology 326 , 36-43, (2014)

Pharmacological evidence has accumulated showing that glucocorticoids and glucocorticoid receptor (GR) facilitate several responses to different drugs of abuse. Recent findings have attributed a prominent role to the mineralocorticoid receptor (MR) in modulat...