依匹唑
依匹唑结构式
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常用名 | 依匹唑 | 英文名 | Epirizole |
|---|---|---|---|---|
| CAS号 | 18694-40-1 | 分子量 | 234.25400 | |
| 密度 | 1.25g/cm3 | 沸点 | 444ºC at 760mmHg | |
| 分子式 | C11H14N4O2 | 熔点 | 90 - 92ºC | |
| MSDS | 中文版 美版 | 闪点 | 222.3ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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Chemical screen identifies FDA-approved drugs and target pathways that induce precocious pancreatic endocrine differentiation.
Proc. Natl. Acad. Sci. U. S. A. 108(48) , 19264-9, (2011) Pancreatic β-cells are an essential source of insulin and their destruction because of autoimmunity causes type I diabetes. We conducted a chemical screen to identify compounds that would induce the differentiation of insulin-producing β-cells in vivo. To do ... |
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Role of active oxygen species and lipid peroxidation in mepirizole-induced duodenal ulcers in rats.
Dig. Dis. Sci. 43(8) , 1657-64, (1998) The role of active oxygen species and lipid peroxidation in the pathogenesis of duodenal ulcers induced by mepirizole was investigated in rats. Oral administration of mepirizole (200 mg/kg) resulted in ulcer lesions in the proximal duodenum. Thiobarbituric ac... |
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Tobacco cigarette smoke attenuates duodenal ulcer margin hyperemia in the rat. Comparison of IAP clearance and hydrogen gas clearance techniques for measurements of gastrointestinal blood flow.
Dig. Dis. Sci. 40(5) , 1112-7, (1995) The hyperemia at the duodenal ulcer margin is important for ulcer healing. We studied the effect of tobacco cigarette smoke on the hyperemia at the margin of mepirizole-induced duodenal ulcer. Duodenal mucosal blood flow values measured by iodo[14C]antipyrine... |
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Effects of pituitary adenylate cyclase activating polypeptide-27 on alkaline secretory and mucosal ulcerogenic responses in rat duodenum.
Life Sci. 63(5) , 317-25, (1998) Effects of pituitary adenylate cyclase activating polypeptide (PACAP) on duodenal mucosal HCO3- secretion and ulcerogenic responses induced by mepirizole in anesthetized rats were examined and compared with those of vasoactive intestinal polypeptide (VIP). An... |
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Biochemical and pharmacological properties of a newly synthesized proton pump (H+/K(+)-ATPase) inhibitor, TY-11345 in experimental animals.
Jpn. J. Pharmacol. 62(4) , 363-71, (1993) We investigated the effects of the newly synthesized proton pump inhibitor TY-11345, (+/-)-2-[(4-methoxy-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin- 9-yl)sulfinyl]-1H-benzimidazole sodium salt, on gastric mucosal proton pump (H+/K(+)-ATPase) activity, gastric... |
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Biochemical and pharmacological properties of a new proton pump inhibitor, 2-amino-4,5-dihydropyrido[1,2-a]thiazolo [5,4-g] benzimidazole (YJA20379-5).
Arch. Pharm. Res. 21(3) , 241-7, (1998) This study was designed to determine biochemical and pharmacological properties of a newly synthesized benzimidazole derivative, 2-amino-4,5-dihydropyrido [1,2-a] thiazolo [5,4-g] benzimidazole (YJA20379-5) in vitro and in vivo. In the leaky membrane vesicles... |
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Duodenal SP-like immunoreactivity is decreased in experimentally-induced duodenal ulcers.
Neurosci. Lett. 112(2-3) , 352-5, (1990) Substance P-like immunoreactivity (SP-li) is decreased in duodenal samples of animals treated with a single dose of an ulcerogen such as dulcerozine, mepirizole or cysteamine. Unlike dulcerozine- or mepirizole-induced ulcers the degree of cysteamine-induced d... |
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The biochemical and pharmacological properties of a newly synthesized H+-K+ ATPase inhibitor, 2-dimethylamino-4,5-dihydrothiazolo[4,5:3,4]pyridol-[1,2-a]benzimidazol e.
Can. J. Physiol. Pharmacol. 76(9) , 921-9, (1998) This study was designed to determine the effect of a newly synthesized proton pump inhibitor, 2-dimethylamino-4,5-dihydrothiazolo[4,5:3,4]pyridol[1,2-a]be nzimidazole (YJA20379-2), on gastric H(+)-K(+) ATPase activity, acid secretion, and experimental gastrod... |
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Effects of endothelin-1 on duodenal bicarbonate secretion and mucosal integrity in rats.
Chin. J. Physiol. 42(3) , 129-35, (1999) Effects of endothelin-1 on gastric acid secretion, duodenal HCO3- secretion, and duodenal mucosal integrity were investigated in anesthetized rats, in comparison with those of TY-10957, a stable analogue of prostacyclin. A rat stomach mounted on an ex-vivo ch... |
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Gastric antisecretory and anti-ulcer effect of ME3407, a new benzimidazole derivative, in rats.
Arzneimittelforschung 54(4) , 221-9, (2004) The effects of a new benzimidazole derivative, ME3407 (n-butyl-2-(thiazolo-[5,4-b]pyrid-2-yl) sulfinylacetate, CAS 133903-90-9), on gastric acid secretion and gastric and duodenal ulcers in rats were examined. ME3407, given orally, inhibited dose-dependently ... |