4-乙酰氨-2,2,6,6-四甲基哌啶-1-氧
4-乙酰氨-2,2,6,6-四甲基哌啶-1-氧结构式
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常用名 | 4-乙酰氨-2,2,6,6-四甲基哌啶-1-氧 | 英文名 | 4-Acetamido-TEMPO, free radical |
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| CAS号 | 14691-89-5 | 分子量 | 213.297 | |
| 密度 | N/A | 沸点 | 368.8ºC at 760 mmHg | |
| 分子式 | C11H21N2O2 | 熔点 | 143-145 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 176.8ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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Tempace and troxyl-novel synthesized 2,2,6,6-tetramethylpiperidine derivatives as antioxidants and radioprotectors.
Biochem. Mol. Biol. Int. 40(6) , 1211-9, (1996) Two novel 2,2,6,6-tetramethylpiperidine derivatives (Tempace and Troxyl) were synthesized and their capacity to act as scavengers of superoxide, inhibitors of iron and ascorbate-driven Fenton reaction and radioprotectors was tested. The possibility for one-el... |
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Rutoxyl [rutin/4-acetamide-1-hydroxy-2,2,6,6-tetramethylpiperidinium] is a new member of the class of semi-natural products of high pharmacological potency.
Biochem. Mol. Biol. Int. 42(6) , 1261-70, (1997) A novel complex, Rutoxyl [rutin/4-acetamide-1-hydroxy-2,2,6,6-tetramethylpiperidinium] was synthesized and its structure and anticancer activity were investigated. The results reported here are consistent with our idea, that the formation of such a complex of... |
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Different effectiveness of piperidine nitroxides against oxidative stress induced by doxorubicin and hydrogen peroxide.
Cell Biol. Toxicol. 24(1) , 101-12, (2008) The piperidine nitroxides Tempamine and Tempace have been studied for their effect on doxorubicin (DOX) and hydrogen peroxide (H(2)O(2)) cytotoxicity in immortalized B14 cells, a model for neoplastic phenotype. The significance for nitroxide performance of th... |
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Antiproliferative and cytotoxic effects of N,N-diethylaminoethyl ethers of flavanone oximes: a comparison with anthracycline(s), anthraquinone and nitroxides action.
Anticancer Res. 19(2A) , 1255-60, (1999) Since flavanone oximes derivatives (ethers) have been shown to modulate the growth of Yoshida Sarcoma cells in vivo and to induce apoptosis, the effects of these substances on immortalized cell lines growth were examined. Cell viability and sensitivity to inv... |
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Tempicol-3, a novel piperidine-N-oxide stable radical and antioxidant, with low toxicity acts as apoptosis inducer and cell proliferation modifier of Yoshida Sarcoma cells in vivo.
Anticancer Res. 20(6B) , 4611-8, (2000) The novel nitroxyl, Tempicol-3 (nitroxide-N-oxide) was synthesized and its capacity to act as a scavenger of hydroxyl radicals was tested. The concentration-dependent reducibility of this novel compound was also examined and compared with those of previously ... |
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Metal-Free Oxidation of Primary Amines to Nitriles through Coupled Catalytic Cycles.
Chemistry 22(15) , 5156-9, (2016) Synergism among several intertwined catalytic cycles allows for selective, room temperature oxidation of primary amines to the corresponding nitriles in 85-98% isolated yield. This metal-free, scalable, operationally simple method employs a catalytic quantity... |
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Structural characteristics and antioxidant activities of different families of 4-acetamido-TEMPO-oxidised curdlan.
Food Chem. 143 , 530-5, (2014) Regioselective oxidation was applied to commercial curdlan for the preparation of its water-soluble derivatives with improved antioxidant activities, using a 4-acetamido-2,2, 6,6-tetramethylpiperidine-1-oxyl radical/NaClO/NaClO2 system at pH 4.8 and 40°C. The... |
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Preparation of completely C6-carboxylated curdlan by catalytic oxidation with 4-acetamido-TEMPO.
Carbohydr. Polym. 100 , 74-9, (2014) Pure (1→3)-β-polyglucuronic acid sodium salt was prepared from curdlan by oxidation with 4-acetamido-TEMPO/NaClO/NaClO₂ in water at pH 4.7 and 35°C. The oxidation conditions, including the reaction time and amounts of reagents added, were optimized for the pr... |
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J. Org. Chem. 56 , 6110, (1991)
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Iron Chloride/4-Acetamido-TEMPO/Sodium Nitrite-Catalyzed Aerobic Oxidation of Primary Alcohols to the Aldehydes. Yin W, et al.
Adv. Synth. Catal. 352(1 , 113-118, (2010)
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