K-Ras ligand-Linker Conjugate 4 structure
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Common Name | K-Ras ligand-Linker Conjugate 4 | ||
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CAS Number | 2378261-83-5 | Molecular Weight | 697.82 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C35H51N7O8 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of K-Ras ligand-Linker Conjugate 4K-Ras ligand-Linker Conjugate 4 incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 4 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells[1]. |
Name | K-Ras ligand-Linker Conjugate 4 |
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Description | K-Ras ligand-Linker Conjugate 4 incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 4 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells[1]. |
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Related Catalog | |
In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
References |
[1]. CREW, Andrew P., et al. MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE. WO2019195609A2. |
Molecular Formula | C35H51N7O8 |
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Molecular Weight | 697.82 |
Hazard Codes | Xi |
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