2378261-85-7
2378261-85-7 structure
- Name: K-Ras ligand-Linker Conjugate 5
- Chemical Name: K-Ras ligand-Linker Conjugate 5
- CAS Number: 2378261-85-7
- Molecular Formula: C42H59N7O8
- Molecular Weight: 789.96
- Catalog: Research Areas Cancer
- Create Date: 2020-05-01 14:11:10
- Modify Date: 2025-09-12 12:10:59
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K-Ras ligand-Linker Conjugate 5 incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 5 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells[1].
| Name | K-Ras ligand-Linker Conjugate 5 |
|---|
| Description | K-Ras ligand-Linker Conjugate 5 incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 5 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells[1]. |
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| Related Catalog | |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
[1]. CREW, Andrew P., et al. MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE. WO2019195609A2. |
| Molecular Formula | C42H59N7O8 |
|---|---|
| Molecular Weight | 789.96 |
| Hazard Codes | Xi |
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