K-Ras ligand-Linker Conjugate 5

Modify Date: 2024-01-18 08:54:20

K-Ras ligand-Linker Conjugate 5 structure	Common Name	K-Ras ligand-Linker Conjugate 5
	CAS Number	2378261-85-7	Molecular Weight	789.96
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₄₂H₅₉N₇O₈	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of K-Ras ligand-Linker Conjugate 5

K-Ras ligand-Linker Conjugate 5 incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 5 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells[1].

Name	K-Ras ligand-Linker Conjugate 5

Description	K-Ras ligand-Linker Conjugate 5 incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 5 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells[1].
Related Catalog	Research Areas >> Cancer
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. CREW, Andrew P., et al. MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE. WO2019195609A2.

Molecular Formula	C₄₂H₅₉N₇O₈
Molecular Weight	789.96

Hazard Codes	Xi

K-Ras ligand-Linker Conjugate 5

Use of K-Ras ligand-Linker Conjugate 5

Names

K-Ras ligand-Linker Conjugate 5 Biological Activity

Chemical & Physical Properties

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