2093388-45-3

2093388-45-3 structure

Name: E3 Ligand-Linker Conjugate 4
Chemical Name: E3 ligase Ligand 9
CAS Number: 2093388-45-3
Molecular Formula: C₁₈H₂₃N₃O₃
Molecular Weight: 329.39
Catalog: Signaling Pathways PROTAC PROTAC
Create Date: 2019-06-02 10:39:56
Modify Date: 2024-01-02 08:57:44
E3 ligase Ligand 9 is a Ligand of BETd-260 for E3 Ligase used in PROTAC. BETd-260 is a potent BET degrader based on PROTAC technology, with an IC50 of 51 pM against BRD4 protein in RS4;11 leukemia cell line[1].

Name	E3 ligase Ligand 9

Description	E3 ligase Ligand 9 is a Ligand of BETd-260 for E3 Ligase used in PROTAC. BETd-260 is a potent BET degrader based on PROTAC technology, with an IC50 of 51 pM against BRD4 protein in RS4;11 leukemia cell line[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Signaling Pathways >> PROTAC >> Ligand for E3 Ligase
Target	E3 ligase[1].
References	[1]. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481.