Dopamine serotonin antagonist-1

Modify Date: 2024-01-05 01:21:25

Dopamine serotonin antagonist-1 structure	Common Name	Dopamine serotonin antagonist-1
	CAS Number	1977-07-7	Molecular Weight	292.37800
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₈H₂₀N₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Dopamine serotonin antagonist-1

Dopamine serotonin antagonist-1 is a dual dopamine and serotonin receptor antagonist with Kis of 200, 2500, 420, 39, 84, 40 nM for dopamine D1, D2,D4, and serotonin S2A, S2C, S3, respectively.

Name	6-(4-methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepine
Synonym	More Synonyms

Description	Dopamine serotonin antagonist-1 is a dual dopamine and serotonin receptor antagonist with Kis of 200, 2500, 420, 39, 84, 40 nM for dopamine D1, D2,D4, and serotonin S2A, S2C, S3, respectively.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Serotonin Transporter Research Areas >> Neurological Disease
Target	Ki: 200 nM (Dopamne D1), 2500 nM (Dopamne D2), 420 nM (Dopamne D4), 39 nM (Serotonin S2A), 84 nM (Serotonin S2C), 200 nM (Serotonin S3)[1]
Kinase Assay	To measure the affinity for the serotonin 5-3 (6-HTs) receptor, membranes from confluent NG108-15 cell monolayers are prepared and stored. The assay tubes, in triplicate, receive 100 μL of 1 nM [3H]GR65630, 50 μL of test compound (include Dopamine serotonin antagonist-1) or 10 pM metoclopramide for nonspecific binding, 200 μL membrane suspension (0.1 to 0.2 mglassay tube) in a final volume of 500 μL. Incubation proceeds at 37°C for 30 min and is terminated by filtration of the mixture through GF/B glass fiber filters, presoaked in 0.1% polyethylenimine, using a Brandel cell harvester. The filters are rinsed with two 5-mL portions of ice-cold HEPES-KOH, pH 7.4, buffer. The filters are transferred to scintillation vials to which 4 mL of Beckman Ready Protein is added, and the radioactivity is determined by liquid scintillation spectrometry[1].
References	[1]. Phillips ST, et al. Binding of 5H-dibenzo[b,e][1,4]diazepine and chiral 5H-dibenzo[a,d]cycloheptene analogues of clozapine to dopamine and serotonin receptors. J Med Chem. 1994 Aug 19;37(17):2686-96.

Molecular Formula	C₁₈H₂₀N₄
Molecular Weight	292.37800
Exact Mass	292.16900
PSA	30.87000
LogP	2.51870
Vapour Pressure	1.48E-08mmHg at 25°C
Storage condition	2-8℃

Dechloroclozapine

Dopamine serotonin antagonist-1

Dopamine serotonin antagonist-1

Use of Dopamine serotonin antagonist-1

Names

Dopamine serotonin antagonist-1 Biological Activity

Chemical & Physical Properties

Synonyms