GPR40 agonist 6 structure
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Common Name | GPR40 agonist 6 | ||
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CAS Number | 1798751-25-3 | Molecular Weight | 337.37 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C20H19NO4 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of GPR40 agonist 6GPR40 agonist 6 (Compound 7a) is a potent and selective free fatty acid receptor 1 (FFAR1 or GPR40) agonist with an EC50 of 0.058 μM[1]. |
Name | GPR40 agonist 6 |
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Description | GPR40 agonist 6 (Compound 7a) is a potent and selective free fatty acid receptor 1 (FFAR1 or GPR40) agonist with an EC50 of 0.058 μM[1]. |
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Related Catalog | |
Target |
EC50: 0.058 μM (GPR40)[1] |
In Vitro | GPR40 agonist 6 (Compound 7a) shows a very favorable ADME profile, and shows no significant inhibition of the principal cytochrome P450 isoforms (1A2, 2C9, 2C19, 2D6 and 3A4) at 5 µM[1]. ADME profile for GPR40 agonist 6 (Compound 7a)[1] GPR40 agonist 6 (Compound 7a) Plasma protein binding (human)a 98.6% Aqueous solubility (PBS, pH 7.4)b 404 µM Microsomal stability (mouse, t1/2)c 434 min A-B permeability (Caco-2, cm•s-1)d 15.2 • 10-6 aEach value is an average of n = 4, measured at c = 1 µM. bEach value is an average of n = 2. cEach value is an average of n = 5, measured at c = 2 µM. dEach value is an average of n = 2, measured at c = 10 µM. |
References |
Molecular Formula | C20H19NO4 |
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Molecular Weight | 337.37 |