1887161-80-9
1887161-80-9 structure
- Name: RORγt Inverse agonist 6
- Chemical Name: RORγt Inverse agonist 6
- CAS Number: 1887161-80-9
- Molecular Formula: C28H29ClN6O5
- Molecular Weight: 565.02
- Catalog: Signaling Pathways Metabolic Enzyme/Protease ROR
- Create Date: 2019-12-07 23:57:54
- Modify Date: 2025-08-27 17:23:26
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RORγt Inverse agonist 6 (compound 43) is a RORγt inverse agonist for the treatment of Th17-driven autoimmune diseases. RORγt Inverse agonist 6 (compound 43) suppresses IL-17A gene expression by IL-23 stimulation in vivo[1].
| Name | RORγt Inverse agonist 6 |
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| Description | RORγt Inverse agonist 6 (compound 43) is a RORγt inverse agonist for the treatment of Th17-driven autoimmune diseases. RORγt Inverse agonist 6 (compound 43) suppresses IL-17A gene expression by IL-23 stimulation in vivo[1]. |
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| Related Catalog | |
| In Vivo | RORγt Inverse agonist 6 (compound 43) suppresses IL-17A gene expression by IL-23 stimulation in a mouse pharmacodynamics model[1]. RORγt Inverse agonist 6 (compound 43) exhibits improved drug exposure (mouse AUC: 1289 ng•h/mL at 1 mg/kg, po)[1]. RORγt Inverse agonist 6 (compound 43, 30 mg/kg, po, b.i.d) inhibits the expression level of IL-17A by 59% compared to the vehicle after the oral administration at the tested dose[1]. Animal Model: Mice[1]. Dosage: 30 mg/kg. Administration: Orally twice: at 30 min before and 8 h after IL-23 administration. Result: Inhibited the expression level of IL-17A by 59% compared to the vehicle after the oral administration at the tested dose. |
| References |
| Molecular Formula | C28H29ClN6O5 |
|---|---|
| Molecular Weight | 565.02 |