2443384-60-7

2443384-60-7 structure

Name: GPR40 agonist 5
Chemical Name: GPR40 agonist 5
CAS Number: 2443384-60-7
Molecular Formula: C₂₇H₂₄N₂O₄
Molecular Weight: 440.49
Catalog: Signaling Pathways GPCR/G Protein GPR40
Create Date: 2022-07-01 22:51:21
Modify Date: 2024-01-17 07:51:42
GPR40 agonist 5 (compound I-14) is an orally active and potent GPR40 (G protein coupled receptor 40) agonist, with an EC50 of 47 nM. GPR40 agonist 5 decreases the levels of blood glucose and improves the glucose tolerance. GPR40 agonist 5 has sufficient effectiveness for the control of hyperglycemia state in type 2 diabetic mice[1].

Name	GPR40 agonist 5

Description	GPR40 agonist 5 (compound I-14) is an orally active and potent GPR40 (G protein coupled receptor 40) agonist, with an EC50 of 47 nM. GPR40 agonist 5 decreases the levels of blood glucose and improves the glucose tolerance. GPR40 agonist 5 has sufficient effectiveness for the control of hyperglycemia state in type 2 diabetic mice[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> GPR40 Research Areas >> Metabolic Disease
Target	EC50: 47 ± 9.8 nM (GPR40)[1]
References	[1]. Ye Z, et al. Discovery of novel potent GPR40 agonists containing imidazo[1,2-a]pyridine core as antidiabetic agents. Bioorg Med Chem. 2020 Jul 1;28(13):115574.

Molecular Formula	C₂₇H₂₄N₂O₄
Molecular Weight	440.49