GPR40 agonist 5

Modify Date: 2025-08-25 18:56:32

GPR40 agonist 5 Structure
GPR40 agonist 5 structure
Common Name GPR40 agonist 5
CAS Number 2443384-60-7 Molecular Weight 440.49
Density N/A Boiling Point N/A
Molecular Formula C27H24N2O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of GPR40 agonist 5


GPR40 agonist 5 (compound I-14) is an orally active and potent GPR40 (G protein coupled receptor 40) agonist, with an EC50 of 47 nM. GPR40 agonist 5 decreases the levels of blood glucose and improves the glucose tolerance. GPR40 agonist 5 has sufficient effectiveness for the control of hyperglycemia state in type 2 diabetic mice[1].

 Names

Name GPR40 agonist 5

 GPR40 agonist 5 Biological Activity

Description GPR40 agonist 5 (compound I-14) is an orally active and potent GPR40 (G protein coupled receptor 40) agonist, with an EC50 of 47 nM. GPR40 agonist 5 decreases the levels of blood glucose and improves the glucose tolerance. GPR40 agonist 5 has sufficient effectiveness for the control of hyperglycemia state in type 2 diabetic mice[1].
Related Catalog
Target

EC50: 47 ± 9.8 nM (GPR40)[1]

References

[1]. Ye Z, et al. Discovery of novel potent GPR40 agonists containing imidazo[1,2-a]pyridine core as antidiabetic agents. Bioorg Med Chem. 2020 Jul 1;28(13):115574.

 Chemical & Physical Properties

Molecular Formula C27H24N2O4
Molecular Weight 440.49
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