hMAO-B-IN-4

Modify Date: 2024-04-03 10:45:40

hMAO-B-IN-4 structure	Common Name	hMAO-B-IN-4
	CAS Number	1666119-75-0	Molecular Weight	320.40
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₁₆O₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of hMAO-B-IN-4

hMAO-B-IN-4 (compound B10) is a selective, reversible and blood–brain barrier (BBB) penetrable human monoamine oxidase-B (hMAO-B) inhibitor with an IC50 value and a Ki value of 0.067 and 0.03 μM, respectively. hMAO-B-IN-4 inhibits hMAO-A with an IC50 value of 33.82 μM. hMAO-B-IN-4 can be used for Alzheimer’s disease (AD) and Parkinson’s disease (PD) research[1].

Name	hMAO-B-IN-4

Description	hMAO-B-IN-4 (compound B10) is a selective, reversible and blood–brain barrier (BBB) penetrable human monoamine oxidase-B (hMAO-B) inhibitor with an IC50 value and a Ki value of 0.067 and 0.03 μM, respectively. hMAO-B-IN-4 inhibits hMAO-A with an IC50 value of 33.82 μM. hMAO-B-IN-4 can be used for Alzheimer’s disease (AD) and Parkinson’s disease (PD) research[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Research Areas >> Neurological Disease
In Vitro	hMAO-B-IN-4 (0-40 μM) 对 hMAO-B 相比于 hMAO-A 具有高选择性，SI 值为 504.791[1]。 hMAO-B-IN-4 (0-40 μM) 抑制 hMAO-A 和 hMAO-B，IC50 值分别为 33.821 和 0.067 μM[1]。
References	[1]. Sudevan ST, et al. Introduction of benzyloxy pharmacophore into aryl/heteroaryl chalcone motifs as a new class of monoamine oxidase B inhibitors. Sci Rep. 2022 Dec 27;12(1):22404.

Molecular Formula	C₂₀H₁₆O₂S
Molecular Weight	320.40

hMAO-B-IN-4

Use of hMAO-B-IN-4

Names

hMAO-B-IN-4 Biological Activity

Chemical & Physical Properties