2-propylpiperidine hydrochloride

Modify Date: 2024-01-21 08:11:23

2-propylpiperidine hydrochloride Structure
2-propylpiperidine hydrochloride structure
Common Name 2-propylpiperidine hydrochloride
CAS Number 15991-59-0 Molecular Weight 163.69
Density N/A Boiling Point 166.2ºC at 760 mmHg
Molecular Formula C8H18ClN Melting Point -210ºC(lit.)
MSDS N/A Flash Point 48.4ºC

 Use of 2-propylpiperidine hydrochloride


(±)-Coniine hydrochloride (2-Propylpiperidine hydrochloride) is a potent nAChR agonist with an EC50 value of 0.3 mM. (±)-Coniine hydrochloride shows acute toxicity with an LD50 value of 7.7 mg/kg[1].

 Names

Name (2S)-2-Propylpiperidine hydrochloride (1:1)
Synonym More Synonyms

 2-propylpiperidine hydrochloride Biological Activity

Description (±)-Coniine hydrochloride (2-Propylpiperidine hydrochloride) is a potent nAChR agonist with an EC50 value of 0.3 mM. (±)-Coniine hydrochloride shows acute toxicity with an LD50 value of 7.7 mg/kg[1].
Related Catalog
Target

EC50: 0.3 mM (nAChR)[1]

In Vivo (±)-Coniine hydrochloride (compound 1) (0.05 mg-0.2 mg; i.v.) 具有急性毒性,LD50 值为 7.7 mg/kg[1]。 Animal Model: 15-20 g, Swiss-Webster male mice[1] Dosage: 0.05 mg-0.2 mg Administration: I.v. Result: Clinical signs was almost immediate after injection, beginning with piloerection, tailflicking, and rapidly progressing to intention tremors, clonic convulsions, muscular weakness, lateral recumbency, and death; shows acute toxicity with an LD50 value of 7.7 mg/kg.
References

[1]. Lee ST, et al. Stereoselective potencies and relative toxicities of coniine enantiomers. Chem Res Toxicol. 2008 Oct;21(10):2061-4.  

 Chemical & Physical Properties

Boiling Point 166.2ºC at 760 mmHg
Melting Point -210ºC(lit.)
Molecular Formula C8H18ClN
Molecular Weight 163.69
Flash Point 48.4ºC
Exact Mass 163.11300
PSA 12.03000
LogP 3.05940
Vapour Pressure 1.8mmHg at 25°C

 Safety Information

Hazard Codes Xi: Irritant;
Risk Phrases R36
Safety Phrases S26
HS Code 2933399090

 Customs

HS Code 2933399090
Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

(S)-2,2'-bis(diphenylphosphanyl)-5,5'-dichloro-6,6'-dimethoxy-1,1'-biphenyl
(S)-3,7-Dimethyloct-6-enal
(3S)-3,7-dimethyl-6-octenal
(S)-(+)-coniine*HCl
l-citronellal
(-)-Citronellal
(S)-2-propylpiperidine hydrochloride
(S)-(-)-Citronellal
(S)-(-)-5,5'-dichloro-6,6'-dimethoxy-2,2'-bis(diphenylphosphino)-1,1'-biphenyl
(S)-Cl,OMe-BIPHEP
(S)-coniine hydrochloride
(3S)-(-)-Citronellal
(S)-3,7-Dimethyl-6-octenal
(+)-coniine hydrochloride
(2S)-2-n-propylpiperidine hydrochloride
(R)-Cl,MeO-BIPHEP
(+)-(2S)-2-propylpiperidine hydrochloride
(S)-Cl-MeO-BIPHEP