4-Hydroxyacetophenone

Modify Date: 2025-08-19 21:51:39

4-Hydroxyacetophenone structure	Common Name	4-Hydroxyacetophenone
	CAS Number	99-93-4	Molecular Weight	136.148
	Density	1.1±0.1 g/cm3	Boiling Point	313.0±0.0 °C at 760 mmHg
	Molecular Formula	C₈H₈O₂	Melting Point	132-135 °C(lit.)
	MSDS	Chinese USA	Flash Point	121.2±12.4 °C
	Symbol	GHS07	Signal Word	Warning

Use of 4-Hydroxyacetophenone

4-Hydroxyacetophenone (P-hydroxyacetophenone) is a key hepatoprotective and choleretic compound in Artemisia capillaris and A. morrisonensis, also has an anti-hepatitis B virus effect and anti-inflammatory effect[1].

Name	4'-hydroxyacetophenone
Synonym	More Synonyms

Description	4-Hydroxyacetophenone (P-hydroxyacetophenone) is a key hepatoprotective and choleretic compound in Artemisia capillaris and A. morrisonensis, also has an anti-hepatitis B virus effect and anti-inflammatory effect[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
References	[1]. Ching-Wen C, et al. p-Hydroxyacetophenone suppresses nuclear factor-κB-related inflammation in nociceptive and inflammatory animal models. J Nat Med. 2017 Apr;71(2):422-432.

Density	1.1±0.1 g/cm3
Boiling Point	313.0±0.0 °C at 760 mmHg
Melting Point	132-135 °C(lit.)
Molecular Formula	C₈H₈O₂
Molecular Weight	136.148
Flash Point	121.2±12.4 °C
Exact Mass	136.052429
PSA	37.30000
LogP	1.42
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.552
Storage condition	Refrigerator
Water Solubility	10 g/L (22 ºC)

4-Hydroxyacetophenone MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AM8750000

CHEMICAL NAME :: Acetophenone, p-hydroxy-

CAS REGISTRY NUMBER :: 99-93-4

LAST UPDATED :: 199710

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C8-H8-O2

MOLECULAR WEIGHT :: 136.16

WISWESSER LINE NOTATION :: QR DV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MEXPAG Medicina Experimentalis. (Basel, Switzerland) V.1-11, 1959-64; V.18-19, 1968-69. For publisher information, see JNMDBO. Volume(issue)/page/year: 11,137,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1 gm/kg

SEX/DURATION :: female 11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 41,43,1990

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful
Risk Phrases	R22;R36/37/38
Safety Phrases	S26-S36/37-S37/39-S24/25-S22
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	PC4959775
HS Code	2914509090

Precursor 10
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DownStream 10
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CAS#:4074-51-5 4-Isopropoxyace... CAS#:34221-41-5 Echinatin

HS Code	2914501900
Summary	2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Convenient QSAR model for predicting the complexation of structurally diverse compounds with β-cyclodextrins

Bioorg. Med. Chem. 17 , 896-904, (2009)

This paper reports a QSAR study for predicting the complexation of a large and heterogeneous variety of substances (233 organic compounds) with beta-cyclodextrins (beta-CDs). Several different theoret...

Cellular apoptosis and cytotoxicity of phenolic compounds: a quantitative structure-activity relationship study.

J. Med. Chem. 48 , 7234-42, (2005)

In this comprehensive study on the caspase-mediated apoptosis-inducing effect of 51 substituted phenols in a murine leukemia cell line (L1210), we determined the concentrations needed to induce caspas...

Development of an analytical method for the targeted screening and multi-residue quantification of environmental contaminants in urine by liquid chromatography coupled to high resolution mass spectrometry for evaluation of human exposures.

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The aim of this study was to develop an analytical method and contribute to the assessment of the Exposome. Thus, a targeted analysis of a wide range of contaminants in contact with humans on daily ro...

1-(4-Hydroxyphenyl)ethan-1-one

Piceol

1-Acetyl-4-hydroxybenzene

4'-Hydroxyacetophenone

QR DV1

EINECS 202-802-8

4-Acetylphenol

4-Hydroxyacetophenone

p-Acetylphenol

Phenol, p-acetyl-

Acetophenone, p-hydroxy-

p-Hydroxyphenyl methyl ketone

(4-Hydroxyphenyl)ethan-1-one

1-(4-Hydroxyphenyl)ethanone

Ethanone, 1-(4-hydroxyphenyl)-

4′-Hydroxyacetophenone

MFCD00002355

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