Ciprofloxacin Lactate Soluble

Modify Date: 2024-01-02 05:07:11

Ciprofloxacin Lactate Soluble structure	Common Name	Ciprofloxacin Lactate Soluble
	CAS Number	97867-33-9	Molecular Weight	403.404
	Density	1.4±0.1 g/cm3	Boiling Point	656.4±55.0 °C at 760 mmHg
	Molecular Formula	C₂₀H₂₄FN₃O₆	Melting Point	255-257ºC
	MSDS	N/A	Flash Point	350.8±31.5 °C

Use of Ciprofloxacin Lactate Soluble

Ciprofloxacin (Bay-09867) lactate is a potent, orally active topoisomerase IV inhibitor. Ciprofloxacin lactate induces mitochondrial DNA and nuclear DNA damage and lead to mitochondrial dysfunction, ROS production. Ciprofloxacin lactate has anti-proliferative activity and induces apoptosis. Ciprofloxacin lactate is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity[1][2][3][4].

Name	1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid,2-hydroxypropanoic acid
Synonym	More Synonyms

Description	Ciprofloxacin (Bay-09867) lactate is a potent, orally active topoisomerase IV inhibitor. Ciprofloxacin lactate induces mitochondrial DNA and nuclear DNA damage and lead to mitochondrial dysfunction, ROS production. Ciprofloxacin lactate has anti-proliferative activity and induces apoptosis. Ciprofloxacin lactate is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity[1][2][3][4].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Ciprofloxacin (Bay-09867) lactate (5-50 μg/mL; 0-24 h; tendon cells) inhibits cell proliferation and causes cell cycle arrest at the G2/M phase[1]. Ciprofloxacin (Bay-09867) lactate shows potent activity against Y. pestis and B. anthracis with MIC90 of 0.03 μg/mL and 0.12 μg/mL, respectively[2]. Cell Cycle Analysis[1] Cell Line: Tendon cells Concentration: 5, 10, 20 and 50 μg/mL Incubation Time: 24 hours Result: Decreased the cellularity of tendon cells. Apoptosis Analysis[1] Cell Line: Tendon cells Concentration: 50 μg/mL Incubation Time: 24 hours Result: Arrested cell cycle at the G2/M phase and inhibited cell division in tendon cells. Western Blot Analysis[1] Cell Line: Tendon cells Concentration: 50 μg/mL Incubation Time: 0, 6, 12, 17 and 24 hours Result: Down-regulated the expression of CDK-1 and cyclin B protein and mRNA. Up-regulated the expression of PLK-1 protein.
In Vivo	Ciprofloxacin (Bay-09867) lactate (30 mg/kg; i.p.; for 24 hours; BALB/c mice) has protection against Y. pestis in murine model of pneumonic plague[3]. Ciprofloxacin (Bay-09867) lactate (100 mg/kg; i.g.; daily, for 4 weeks; C57BL/6J mice) accelerates aortic root enlargement and increases the incidence of aortic dissection and rupture by decreases LOX level and increases MMP levels and activity in the aortic wall[4]. Ciprofloxacin (Bay-09867) lactate (100 mg/kg; i.g.; daily, for 4 weeks; C57BL/6J mice) induces DNA damage and release of DNA to the cytosol, mitochondrial dysfunction, and activation of cytosolic DNA sensor signaling. Ciprofloxacin lactate increases apoptosis and necroptosis in the aortic wall[4]. Animal Model: BALB/c mice[3] Dosage: 30 mg/kg Administration: Intraperitoneal injection; for 24 hours Result: Reduced the lung bacterial load in murine model of pneumonic plague. Animal Model: C57BL/6J mice[4] Dosage: 100 mg/kg Administration: Oral gavage; daily, for 4 weeks Result: Had aortic destruction that was accompanied by decreased LOX expression and increased MMP expression and activity. Animal Model: C57BL/6J mice[4] Dosage: 100 mg/kg Administration: Oral gavage; daily, for 4 weeks Result: Caused mitochondrial DNA and nuclear DNA damage, leading to mitochondrial dysfunction and ROS production. Increased apoptosis and necroptosis in the aortic wall.
References	[1]. Tsai WC, et, al. Ciprofloxacin-mediated cell proliferation inhibition and G2/M cell cycle arrest in rat tendon cells. Arthritis Rheum. 2008 Jun;58(6):1657-63. [2]. Steenbergen J, et, al. In Vitro and In Vivo Activity of Omadacycline against Two Biothreat Pathogens, Bacillus anthracis and Yersinia pestis. Antimicrob Agents Chemother. 2017 Apr 24;61(5):e02434-16. [3]. Hamblin KA, et, al. Inhaled Liposomal Ciprofloxacin Protects against a Lethal Infection in a Murine Model of Pneumonic Plague. Front Microbiol. 2017 Feb 6;8:91. [4]. LeMaire SA, et, al. Effect of Ciprofloxacin on Susceptibility to Aortic Dissection and Rupture in Mice. JAMA Surg. 2018 Sep 1;153(9):e181804.

Density	1.4±0.1 g/cm3
Boiling Point	656.4±55.0 °C at 760 mmHg
Melting Point	255-257ºC
Molecular Formula	C₂₀H₂₄FN₃O₆
Molecular Weight	403.404
Flash Point	350.8±31.5 °C
Exact Mass	403.154358
PSA	100.87000
LogP	0.04
Vapour Pressure	0.0±2.1 mmHg at 25°C
Index of Refraction	1.624

Hazard Codes	Xi
HS Code	2933491000

HS Code	2933491000
Summary	2933491000. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:6.5%. General tariff:20.0%

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1-Cyclopropyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydro-3-quinolinecarboxylic 2-hydroxypropanoic anhydride

MFCD01759747

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Ciprofloxacin Lactate Soluble
Price: ￥678.0/100mg
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Ciprofloxacin lactate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: Ciprofloxacin lactate
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

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